Intrinsic physiological properties of rat retinal ganglion cells with a comparative analysis.
Intrinsic physiological properties of rat retinal ganglion cells with a comparative analysis.
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大鼠视网膜神经节细胞内在生理特性的比较分析。
DOI：
10.1152/jn.01091.2011
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发表时间：
2012
影响因子：
2.5
通讯作者：
B. O'Brien
中科院分区：
文献类型：
--
作者：
Raymond C. S. Wong;S. Cloherty;M. Ibbotson;B. O'Brien
哺乳动物视网膜包含15-20种不同的视网膜神经节细胞（RGC）类型，每种类型负责编码视觉场景的不同方面。编码由RGC突触输入、所使用的神经递质系统及其内在生理特性的组合来定义。每个细胞的内在特性由其形态和膜特征定义，包括所表达的离子通道的互补和定位。在这项研究中，我们研究的假设，个别RGC类型的内在属性是保守的哺乳动物物种。为此，我们测量了16种形态学定义的大鼠RGC类型的内在特性，并将这些数据与猫RGC类型进行了比较。我们的数据表明，在大鼠不同的形态学定义的RGC类型有不同的模式的内在属性。这些性质在不同细胞类型中的变化与猫RGC类型中发现的变化相当。当直接比较大鼠和猫视网膜中假定的形态同源物时，一些RGC类型具有非常相似的特性。大鼠A2细胞表现出的模式的内在特性几乎相同的猫α细胞。相比之下，大鼠D2细胞（开-关定向选择性）具有与猫细胞非常不同的固有特性模式。我们的数据表明，具有相似形态和疑似视觉功能的RGCs的内在特性可能会因物种的行为需求而发生变化。
Mammalian retina contains 15-20 different retinal ganglion cell (RGC) types, each of which is responsible for encoding different aspects of the visual scene. The encoding is defined by a combination of RGC synaptic inputs, the neurotransmitter systems used, and their intrinsic physiological properties. Each cell's intrinsic properties are defined by its morphology and membrane characteristics, including the complement and localization of the ion channels expressed. In this study, we examined the hypothesis that the intrinsic properties of individual RGC types are conserved among mammalian species. To do so, we measured the intrinsic properties of 16 morphologically defined rat RGC types and compared these data with cat RGC types. Our data demonstrate that in the rat different morphologically defined RGC types have distinct patterns of intrinsic properties. Variation in these properties across cell types was comparable to that found for cat RGC types. When presumed morphological homologs in rat and cat retina were compared directly, some RGC types had very similar properties. The rat A2 cell exhibited patterns of intrinsic properties nearly identical to the cat alpha cell. In contrast, rat D2 cells (ON-OFF directionally selective) had a very different pattern of intrinsic properties than the cat iota cell. Our data suggest that the intrinsic properties of RGCs with similar morphology and suspected visual function may be subject to variation due to the behavioral needs of the species.
影响因子：
2.5
作者：
Fohlmeister, JF;Miller, RF
通讯作者：
Miller, RF
脊椎动物视网膜神经节细胞的异质内在放电特性。
DOI：
--
发表时间：
2002
期刊：
J.Neurophysiol. 87
影响因子：
--
作者：
Tabata;T.
通讯作者：
T.