Prevalence and genotype distribution of cervical human papillomavirus infection among female sex workers in Asia: a systematic literature review and meta-analysis.
Prevalence and genotype distribution of cervical human papillomavirus infection among female sex workers in Asia: a systematic literature review and meta-analysis.
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DOI：
10.1071/sh11066
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发表时间：
2012-05
期刊：
影响因子：
1.6
通讯作者：
Chen XS
中科院分区：
文献类型：
--
作者：
Peng RR;Li HM;Chang H;Li JH;Wang AL;Chen XS
宫颈人乳头瘤病毒（HPV）感染具有高度传播性。虽然全球有许多关于一般女性人群HPV感染的研究，但很少关注亚洲女性性工作者（FSW）。在这项研究中，我们使用了荟萃分析的方法，系统地分析了文献，以阐明亚洲FSW宫颈HPV感染的患病率和基因型分布。在5个数据库中确定了14项符合条件的研究，汇总了来自9个亚洲国家的4198名FSW的数据。该地区FSW宫颈HPV感染率的粗略估计值为12.8%至84.8%。FSW感染HPV的风险是一般女性人群的近10倍。分层分析表明，HPV感染率在东亚高于其他次区域，年轻的FSW比年长的FSW。HPV基因型分布在东亚和东南亚之间有统计学差异。在东亚，最常见的基因型为HPV 16（23.9%）、18（11.0%）、58（9.4%）、56（6.3%）和52（5.3%），而在东南亚，最常见的基因型为HPV 52（12.9%）、16（8.5%）、58（5.2%）、18（5.0%）和66（4.9%）。HPV 31、33和35在这两个亚区域的出现频率较低。HPV感染在一些亚洲国家的FSW中很普遍。需要更多的研究来说明该地区HPV感染的总体情况。
Cervical human papillomavirus (HPV) infection is highly transmissible. Although there are many studies on HPV infection in general population of women globally, little attention has been paid to female sex workers (FSWs) in Asia. In this study, we used a meta-analytic approach to systematically analyse the literature to elucidate the prevalence and genotype distribution of cervical HPV infection among FSWs in Asia. Fourteen eligible studies were identified in five databases, and data including 4198 FSWs from nine Asian countries were aggregated. Crude estimates of cervical HPV prevalence among FSWs in this region ranged from 12.8% to 84.8%. FSWs had a nearly 10-fold risk of HPV infection than the general population of women. Stratified analysis showed that HPV prevalence was higher in East Asia than other subregions and in younger FSWs than older FSWs. HPV genotype distribution was statistically different between East Asia and South-east Asia. In East Asia, the most prevalent genotypes were HPV 16 (23.9%), 18 (11.0%), 58 (9.4%), 56 (6.3%) and 52 (5.3%), while they were HPV 52 (12.9%), 16 (8.5%), 58 (5.2%), 18 (5.0%) and 66 (4.9%) in South-east Asia. HPV 31, 33 and 35 were less frequently found in both subregions. HPV infection was substantial among FSWs in some Asian countries. More studies are necessary to illustrate the overall picture of HPV infection in this region.