Presence of interleukin-17C in the tissue around aseptic loosened implants
Presence of interleukin-17C in the tissue around aseptic loosened implants
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DOI：
10.1007/s00264-013-1812-x
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发表时间：
2013-03
影响因子：
2.7
通讯作者：
C. Hou;Yangchun Zhang;Shiming Yu;Ziqing Li;Qiyi Zhai;Zhanchun Li;Xibao Zhang;Jianhong Xiao;P. Sheng
中科院分区：
文献类型：
--
作者：
C. Hou;Yangchun Zhang;Shiming Yu;Ziqing Li;Qiyi Zhai;Zhanchun Li;Xibao Zhang;Jianhong Xiao;P. Sheng
目的关节置换术中最常见的长期并发症是无菌性松动。巨噬细胞分泌的促炎细胞因子参与无菌性松动。最近，一种新的促炎细胞因子IL-17C被报道通过与促炎细胞因子协同作用参与炎症性疾病。然而，IL-17C与无菌性松动之间的关系尚不清楚。方法在翻修术中收集无菌松动种植体周围组织，采用福尔马林固定石蜡包埋处理。应用免疫荧光法对12例无菌松动植入物周围组织中IL-17C的存在进行了研究。结果免疫荧光法检测无菌松动植入物周围组织中IL-17C蛋白的表达。无菌性松动标本与类风湿关节炎标本（阳性对照）的IL-17C光密度无统计学差异。结论提示IL-17C在无菌性松动中存在。白细胞介素- 17c与无菌松动的炎症有关，可能与无菌松动植入物周围组织的炎症和骨溶解有关。
PurposeThe most common long-term complication of joint arthroplasty is aseptic loosening. The proinflammatory cytokines secreted by macrophages are involved in aseptic loosening. Recently, a novel proinflammatory cytokine IL-17C was reported to participate in inflammatory diseases by synergising with proinflammatory cytokines. However, the relationship between IL-17C and the aseptic loosening is unclear.MethodsThe tissues around aseptic loosened implants were collected during revision surgery and handled by formalin fixation and embedded in paraffin. The presence of IL-17C in the tissues around the aseptic loosened implants was investigated in 12 aseptic loosening patients using immunofluorescence.ResultsThe presence of IL-17C protein in the tissues around aseptic loosened implants was detected by immunofluorescence. There are no statistical differences between optical density of IL-17C in aseptic loosening samples and in rheumatoid arthritis samples (positive control).ConclusionsThese results suggest the presence of IL-17C in aseptic loosening. Interleukin-17C was related to the inflammation of aseptic loosening, possibly by contributing to the inflammation and osteolysis in the tissues surrounding aseptic loosened implants.