Juvenile ossifying fibroma of the jaw: a retrospective study of 15 cases
Juvenile ossifying fibroma of the jaw: a retrospective study of 15 cases
复制标题
DOI：
10.1016/j.ijom.2015.12.004
复制
发表时间：
2016-03-01
影响因子：
2.4
通讯作者：
Xu, L.
中科院分区：
文献类型：
--
作者：
Han, J.;Hu, L.;Xu, L.
青少年骨化性纤维瘤（JOF）患者的治疗仍存在争议。为探讨不同治疗方法与患者预后的关系，对15例颌骨JOF进行了回顾性分析。男性5例，女性10例。患者发病时的年龄范围为7 - 18岁（平均10.9岁）。9例肿瘤位于下颌骨，6例位于上颌骨。这些病例通常临床表现为无痛性颌骨肿胀（9/15，60%）; 40%（6/15）的病例与疼痛、复视、鼻塞和/或快速生长有关。JOF的图像可以显示放射性、混合或磨玻璃样外观。10例为幼年型骨小梁骨化性纤维瘤（JTOF），5例为幼年型砂粒样骨化性纤维瘤（JPOF）。在治疗方案方面，6例患者最初接受根治性手术治疗; 9例患者接受保守治疗，其中6例（6/9，66.7%）有一次或多次复发。在随访期结束时，12例患者没有肿瘤复发的证据，3例患者仍存活。总之，外科医生应根据病变范围、复发状况、生长速度和家庭选择制定手术方案，并对这些患者进行密切随访。
The management of patients with juvenile ossifying fibroma (JOF) remains controversial. To explore the correlations between different treatments and the patient prognosis, 15 cases of JOF of the jaw were reviewed. Five patients were male and 10 were female. Patient age at the time of disease onset ranged from 7 to 18 years (mean 10.9 years). Nine tumours were located in mandible and six in the maxilla. These cases typically manifested clinically as painless swelling of the jaw (9/15, 60%); 40% (6/15) of the cases were associated with pain, diplopia, stuffy nose, and/or rapid growth. Images of JOF can show a radiolucent, mixed, or ground glass-like appearance. Pathological examinations revealed 10 cases of juvenile trabecular ossifying fibroma (JTOF) and five cases of juvenile psammomatoid ossifying fibroma (JPOF). In terms of the treatment plan, six patients initially received radical surgery; nine patients underwent conservative treatment, among whom six (6/9, 66.7%) had one or more recurrence. At the end of the follow-up period, 12 patients had no evidence of tumour recurrence and three cases were alive with a tumour. In summary, surgeons should develop the surgical plan according to the extent of the lesion, relapse status, growth rate, and family choice, and these patients should be followed up closely.