Health-related quality-of-life outcomes following IMRT versus conventional radiotherapy for oropharyngeal squamous cell carcinoma
Health-related quality-of-life outcomes following IMRT versus conventional radiotherapy for oropharyngeal squamous cell carcinoma
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DOI：
10.1016/j.ijrobp.2007.05.003
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发表时间：
2007-12-01
影响因子：
7
通讯作者：
Buatti, John M.
中科院分区：
文献类型：
--
作者：
Yao, Min;Karnell, Lucy H.;Buatti, John M.
目的：比较调强放疗（IMRT）与常规放疗（CRT）治疗口咽鳞状细胞癌患者的健康相关生活质量（HRQOL）结果。患者和方法：从正在进行的纵向结果评估项目的数据库中提取口咽鳞状细胞癌患者。合格标准包括：(1)接受明确放疗，(2)提供治疗后12个月的HRQOL数据。排除了在2002年10月1日之前接受IMRT的7例患者，该患者处于该机构IMRT技术的发展阶段。比较IMRT组与CRT组的HRQOL结果。结果：IMRT治疗26例，CRT治疗27例。IMRT组的患者年龄更大，有更多的晚期疾病，更多的患者同时接受化疗。然而，在治疗后12个月，IMRT组在四个头颈癌特定领域（包括饮食、语言、美学和社会破坏）的平均头颈癌清单得分更高（代表更好的结果）。与IMRT组相比，CRT组限制饮食的患者比例明显更高（48.0%比16.0%,p = 0.032）。治疗3个月后，两组进食评分均较治疗前显著下降。然而，IMRT组在第一年有明显的改善，而CRT组只有很小的改善。结论：与CRT相比，适当给予IMRT可改善口咽癌患者的HRQOL。(c) 2007爱思唯尔公司
Purpose: To compare health-related quality-of-life (HRQOL) outcomes of patients with oropharyngeal squamousm cell carcinoma treated using intensity-modulated radiotherapy (IMRT) vs. conventional radiotherapy (CRT).Patients and Methods: Patients with oropharyngeal squamous cell carcinoma were extracted from the database of an ongoing longitudinal Outcome Assessment Project. Eligible criteria included (1) treated with definitive radiation, and (2) provided 12-month posttreatment HRQOL data. Excluded were 7 patients who received IMRT before October 1, 2002, during this institution's developmental phase of the IMRT technique. The HRQOL outcomes of patients treated with IMRT were compared with those of patients who received CRT.Results: Twenty-six patients treated using IMRT and 27 patients treated using CRT were included. Patients in the IMRT group were older and had more advanced-stage diseases and more patients received concurrent chemotherapy. However, the IMRT group had higher mean Head and Neck Cancer Inventory scores (which represent better outcomes) for each of the four head-and-neck cancer-specific domains, including eating, speech, aesthetics, and social disruption, at 12 months after treatment. A significantly greater percentage of patients in the CRT group had restricted diets compared with those in the IMRT group (48.0 % vs. 16.0 %,p = 0.032). At 3 months after treatment, both groups had significant decreases from pretreatment eating scores. However, the IMRT group had a significant improvement during the first year, but the CRT group had only small improvement.Conclusions: Proper delivery of IMRT can improve HRQOL for patients with oropharyngeal cancer compared with CRT. (c) 2007 Elsevier Inc.