Sacrificial functional polystyrene template to prepare chitosan nanocapsules and in vitro drug release properties
Sacrificial functional polystyrene template to prepare chitosan nanocapsules and in vitro drug release properties
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DOI：
10.1007/s10853-011-5632-3
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发表时间：
2011-05
影响因子：
4.5
通讯作者：
Weijun Liu;Guihuan Chen;Guanghong He;Zhicai He;Z. Qian
中科院分区：
文献类型：
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作者：
Weijun Liu;Guihuan Chen;Guanghong He;Zhicai He;Z. Qian
本研究以羧基功能化的聚苯乙烯(PS)为牺牲模板，以戊二醛为壳层的壳聚糖(CS)为壳，成功制备了生物相容性和生物可降解性的壳聚糖(CS)纳米胶囊。首先，采用无皂乳液聚合法制备单分散功能化PS模板，其粒径约为200 nm。其次，通过在PS模板表面进行化学交联并通过四氢呋喃去除核来制备纳米胶囊。用红外光谱、核磁共振氢谱、场发射扫描电子显微镜和透射电子显微镜对模板和纳米胶囊进行了表征。所有结果都证实了纳米胶囊是通过这种方法获得的。通过将布洛芬溶解在氯仿液滴中制备羧基官能化聚苯乙烯，也可以制备载药纳米胶囊。研究发现，载药后的药物可持续释放长达80h，纳米囊壁具有显著的减慢药物释放速率的作用。
In this study, biocompatible and biodegradable chitosan (CS) nanocapsules are successfully prepared in abundant and easily using carboxyl-functionalized polystyrene (PS) as sacrificial template and cross-linked CS with glutaraldehyde as the shell. First, the monodisperse functionalized PS templates be about 200 nm are made by emulsifier-free emulsion polymerization. Second, nanocapsules are accomplished by fabricating on the basis of chemical cross-linking on the surface of the PS template and removing the core via tetrahydrofuran. The templates and nanocapsules were characterized by FT–IR,1H NMR, FESEM, and TEM. All the results confirmed that the nanocapsules are accomplished via this method. By dissolution of ibuprofen in the chloroform droplets when prepare the carboxyl-functionalized PS, drug-loaded nanocapsules are also fabricated. It is found that the loaded drug can be released again in a sustained manner for up to 80 h. The nanocapsules walls have a prominent effect in slowing down the drug release rate.