Aging of Human Muscle: Understanding Sarcopenia at the Single Muscle Cell Level
Aging of Human Muscle: Understanding Sarcopenia at the Single Muscle Cell Level
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DOI：
10.1016/j.pmr.2011.11.012
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发表时间：
2012-02-01
影响因子：
1.7
通讯作者：
Rodriguez, Natividad
中科院分区：
文献类型：
--
作者：
Frontera, Walter R.;Zayas, Ana Rodriguez;Rodriguez, Natividad
随着年龄的增长，肌肉量的减少，也被称为肌肉减少症，是一个重大的科学和公共卫生问题。在老年男性和女性中，肌肉萎缩与功能丧失和健康状况不佳有关。通过使用单个肌肉纤维的实验，可以增强对人类这一问题的详细了解。肌肉萎缩和肌纤维质量的下降很可能是导致老年人肌肉功能障碍的原因。在单纤维水平上更好地理解肌肉减少症可能会导致设计更有效的康复干预措施。
The loss of muscle mass with age, also known as sarcopenia, is a major scientific and public health problem. Muscle atrophy is associated with the loss of functional capacity and poor health outcomes in elderly men and women. A detailed understanding of this problem in humans can be enhanced by the use of experiments with single muscle fibers. It is likely that both muscle atrophy and a decrease in muscle-fiber quality contribute to muscle dysfunction among the elderly. A better understanding of sarcopenia at the single-fiber level may lead to the design of more effective rehabilitative interventions.