Enhanced gametocyte formation in erythrocyte progenitor cells: a site-specific adaptation by Plasmodium falciparum.
Enhanced gametocyte formation in erythrocyte progenitor cells: a site-specific adaptation by Plasmodium falciparum.
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DOI：
10.1093/infdis/jit309
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发表时间：
2013-10-01
期刊：
影响因子：
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通讯作者：
Gardiner, Donald L
中科院分区：
文献类型：
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作者：
Peatey, Christopher L;Watson, Jolanta A;Gardiner, Donald L
恶性疟原虫的配子体发生对于疟原虫从人到蚊子的传播是必不可少的，但发育中的配子体缺乏细胞粘附所需的表面蛋白的表达。因此，应该从循环中消除，除非它们被隔离在低血流量的区域，如骨髓的细胞外空间。我们的数据表明，配子细胞发生增强的存在下，发现在骨髓中的红系祖细胞。此外，原子力显微镜表明，发育中的配子细胞的红细胞膜弹性发生显着变化，这可能使它们能够保留在骨髓中直至成熟。
Gametocytogenesis by Plasmodium falciparum is essential for transmission of the parasite from human to mosquito, yet developing gametocytes lack expression of surface proteins required for cytoadherence. Therefore, elimination from the circulation should occur unless they are sequestered in regions of low blood flow such as the extracellular spaces of the bone marrow. Our data indicate that gametocytogenesis is enhanced in the presence of erythroid progenitors found within the bone marrow. Furthermore, atomic force microscopy indicates that developing gametocytes undergo remarkable shifts in their erythrocyte membrane elasticity, which may allow them to be retained within the bone marrow until maturation.