A simple catalytic method for the regioselective halogenation of arenes
A simple catalytic method for the regioselective halogenation of arenes
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DOI：
10.1021/ol060747f
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发表时间：
2006-06-08
期刊：
影响因子：
5.2
通讯作者：
Sanford, Melanie S.
中科院分区：
文献类型：
--
作者：
Kalyani, Dipannita;Dick, Allison R.;Sanford, Melanie S.
本文介绍了一种温和的钯催化方法，以n -卤代琥珀酰亚胺为氧化剂，对芳烃碳氢键进行区域选择性氯化、溴化和碘化反应。这些转化已经应用于广泛的底物，并且可以提供与通过传统亲电芳取代反应获得的产物互补的产物。
This paper describes a mild palladium-catalyzed method for the regioselective chlorination, bromination, and iodination of arene C-H bonds using N-halosuccinimides as oxidants. These transformations have been applied to a wide array of substrates and can provide products that are complementary to those obtained via conventional electrophilic aromatic substitution reactions.