Prevention of Prematurity Advances and Opportunities
Prevention of Prematurity Advances and Opportunities
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DOI：
10.1016/j.clp.2018.05.013
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发表时间：
2018-09-01
影响因子：
2.1
通讯作者：
Narasimhan, Sudha Rani
中科院分区：
文献类型：
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作者：
Govindaswami, Balaji;Jegatheesan, Priya;Narasimhan, Sudha Rani
早产（PTB）率差异很大，并有显着的种族和民族差异。虽然因果机制不清楚，社会环境，表型和基因型提供了深入了解预防PTB的途径。数据表明，对当前医疗干预措施的不同反应是可以解释的。目前，预防的重点是尽量减少医源性肺结核和风险降低，特别是在那些与以前的肺结核使用行之有效的医疗和公共卫生战略。未来，预防方法将基于对社会人口学、营养、生活方式以及潜在的个体遗传和表观遗传变异的更好理解。统计方法和“大数据”模型在未来的研究中至关重要。
Preterm birth (PTB) rate varies widely and has significant racial and ethnic disparities. Although causal mechanisms are ill understood, socioenvironment, phenotype, and genotype provide insight into pathways for preventing PTB. Data suggest varied response to current medical interventions is explicable Approved by underlying pharmacogenomics. Currently, prevention focuses on minimizing iatrogenic PTB and risk reduction especially in those with prior PTB using proven medical and public health strategies. In the future, preventive approaches will be based on better understanding of sociodemography, nutrition, lifestyles, and underlying individual genetic and epigenetic variation. Statistical approaches and "big-data" models are critical in future study.