Genomic and nongenomic effects of estrogen in the vasculature
Genomic and nongenomic effects of estrogen in the vasculature
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DOI：
10.1016/s0002-9149(02)02418-9
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发表时间：
2002-07-03
影响因子：
2.8
通讯作者：
Mendelsohn, ME
中科院分区：
文献类型：
--
作者：
Mendelsohn, ME
雌激素对血管既有快速的血管扩张作用，又有长期的作用。雌激素的长期作用至少部分是通过血管细胞基因和蛋白质表达的变化产生的，这些变化由配体激活的转录因子雌激素受体（ER）-α和ER-β介导。雌激素的快速血管舒张作用不需要基因表达的变化，并且是由雌激素刺激的内皮细胞一氧化氮合酶活性增加产生的。这导致一氧化氮介导的血管平滑肌细胞中环磷酸鸟苷的增加，其介导血管舒张。本文就血管生物学的最新进展作一简要综述。(C)2002年，Excerpta Medica，Inc.
Estrogen has both rapid vasodilatory effects and longer-term effects on the vasculature. The longer-term effects of estrogen are produced, at least in part, by changes in vascular cell gene and protein expression that are mediated by the ligand-activated transcription factors, estrogen receptor (ER)-alpha and ER-beta. The rapid vasodilatory effects of estrogen do not require changes in gene expression and are produced by estrogen-stimulated increases in endothelial cell nitric oxide synthase activity. This results in nitric oxide-mediated increases in cyclic guanosine monophosphate in vascular smooth muscle cells, which mediate vasodilatation. This article briefly reviews recent progress in this field of vascular biology. (C) 2002 by Excerpta Medica, Inc.