Chronic unilateral cervical vagotomy reduces renal inflammation, blood pressure, and renal injury in a mouse model of lupus.
Chronic unilateral cervical vagotomy reduces renal inflammation, blood pressure, and renal injury in a mouse model of lupus.
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DOI：
10.1152/ajprenal.00201.2020
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发表时间：
2020-06
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通讯作者：
Grace S. Pham;Caroline Gusson Shimoura;S. Chaudhari;Dennis V Kulp;Keisa W. Mathis
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作者：
Grace S. Pham;Caroline Gusson Shimoura;S. Chaudhari;Dennis V Kulp;Keisa W. Mathis
系统性红斑狼疮（SLE）的特征是慢性肾脏炎症和迷走神经张力减弱形式的自主神经功能障碍引起的高血压。在健康情况下，迷走神经通过胆碱能抗炎通路等机制调节炎症过程;因此，在SLE的情况下，传出迷走神经活动减少可能间接影响肾脏炎症，从而影响高血压。在这项研究中，我们试图研究在慢性炎症性疾病的背景下，破坏迷走神经传递对肾脏炎症和高血压的影响。方法雌性SLE小鼠（NZBWF 1）和对照小鼠（NZW）分别行右侧颈迷走神经切断术或假手术，3周后留置导管测定血压。评估脾脏和肾脏炎症以及肾损伤的指数。结果：单侧迷走神经切断术可减弱SLE引起的平均动脉压、白蛋白排泄率和肾小球硬化的增加。这种保护作用与脾T细胞减少和SLE诱导的肾促炎介质增加减弱有关。结论单侧迷走神经切断术可减轻SLE小鼠肾脏炎症反应，降低血压。迷走神经有无数的功能，也许其他的神经免疫相互作用可以补偿一条神经的结扎。
BACKGROUND Systemic lupus erythematosus (SLE) is characterized by hypertension that results from chronic renal inflammation and dysautonomia in the form of dampened vagal tone. In health, the vagus nerve regulates inflammatory processes through mechanisms like the cholinergic anti-inflammatory pathway; so in the case of SLE, reduced efferent vagus nerve activity may indirectly affect renal inflammation, and therefore hypertension. In this study, we sought to investigate the impact of disrupting vagal neurotransmission on renal inflammation and hypertension in the setting of chronic inflammatory disease. METHODS Female SLE (NZBWF1) and control (NZW) mice were subjected to a right unilateral cervical vagotomy or sham surgery and 3 weeks later were implanted with indwelling catheters to measure blood pressure. Indices of splenic and renal inflammation, as well as renal injury, were assessed. RESULTS Unilateral vagotomy blunted SLE-induced increases in mean arterial pressure, albumin excretion rate, and glomerulosclerosis. This protection was associated with reduced splenic T cells and attenuated SLE-induced increases in renal pro-inflammatory mediators. CONCLUSION In summary, these data indicate that unilateral vagotomy reduces renal inflammation and reduces blood pressure in SLE mice. The vagus nerves have myriad functions and perhaps other neuroimmune interactions compensate for the ligation of one nerve.