Use of Varenicline for 4 Weeks Before Quitting Smoking Decrease in Ad Lib Smoking and Increase in Smoking Cessation Rates
Use of Varenicline for 4 Weeks Before Quitting Smoking Decrease in Ad Lib Smoking and Increase in Smoking Cessation Rates
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DOI：
10.1001/archinternmed.2011.138
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发表时间：
2011-04-25
影响因子：
--
通讯作者：
Dhanji, Al-Rehan
中科院分区：
文献类型：
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作者：
Hajek, Peter;McRobbie, Hayden J.;Dhanji, Al-Rehan
背景：使用varenicline酒石酸盐减轻了戒烟后的不适，但它似乎也减少了与吸烟相关的“奖励”。目前的治疗方案在戒烟前1周开始，主要依赖于第一种机制。我们开始确定是否增加戒烟前的服药时间会降低吸烟的满意度并促进戒烟。方法：在英国伦敦的一家戒烟诊所，101名吸烟者被随机分配到目标戒烟日期（TQD）前4周服用伐尼克兰，或在TQD前3周服用安慰剂，然后在TQD前1周服用伐尼克兰。两组均在TQD后给予标准伐尼克兰治疗3个月。测量包括戒烟前的吸烟满意度和吸烟摄入量，戒烟后的吸烟冲动和戒断不适，以及从TQD持续戒烟至3个月。结果：伐尼克兰预敷降低了戒烟前吸烟的乐趣（P= 0.004）和吸烟摄入量（P= 0.004）
Background: The use of varenicline tartrate alleviates postquit withdrawal discomfort, but it also seems to reduce the "reward" associated with smoking. The current treatment schedule, which commences 1 week before quitting, relies primarily on the first mechanism. We set out to determine whether increasing the prequit medication period renders cigarettes less satisfying and facilitates quitting.Methods: One hundred one smokers attending a stop-smoking clinic in London, United Kingdom, were randomly allocated to receive varenicline for 4 weeks before the target quit date (TQD) or to receive placebo for 3 weeks before the TQD, followed by varenicline for 1 week before the TQD. In both groups, standard varenicline treatment was given for 3 months after the TQD. Measures included smoking satisfaction and smoke intake before quitting, urges to smoke and withdrawal discomfort after quitting, and sustained abstinence from the TQD to 3 months.Results: Varenicline preloading reduced prequit enjoyment of smoking (P=.004) and smoke intake (P