PHYSIOLOGICAL REGULATION OF CIRCADIAN AND PULSATILE THYROTROPIN SECRETION IN NORMAL MAN AND WOMAN
PHYSIOLOGICAL REGULATION OF CIRCADIAN AND PULSATILE THYROTROPIN SECRETION IN NORMAL MAN AND WOMAN
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DOI：
10.1210/jcem-70-2-403
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发表时间：
1990-02-01
影响因子：
5.8
通讯作者：
MUHLEN, AV
中科院分区：
文献类型：
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作者：
BRABANT, G;PRANK, K;MUHLEN, AV
对5例女性和21例健康男性月经时每10分钟采血一次，连续24小时测定TSH的昼夜节律性和脉动性分泌，经计算机辅助分析，平均为9.9.+-。1.7(群集)和11.4.+-。在2000-0400h期间，超过50%的TSH脉冲被检测到，男性和女性在基础平均和脉动性TSH分泌以及对TRH(200ug)的反应方面没有显著差异。4名健康受试者在1个月、2个月和6个月后(2名受试者)重复进行促甲状腺激素分泌分析，结果显示内相关性明显好于个体间(P<；0.0001)。在6名健康男性志愿者中，我们通过急性睡眠停止或一夜睡眠停止后的长时间睡眠来调节TSH的昼夜分泌模式。睡眠停止后夜间TSH分泌增加(平均血清TSH，2.1。+-)。1.3MU/L；平均睡眠时TSH为1.3+-。0.5mU/L(P<；0.05)，而催眠后睡眠几乎完全抑制昼夜节律变化(平均值：TSH，1.1。+-)。0.7亩/L；P<；0.01)。这种调制是由于脉冲幅度的显著降低，而不是由于TSH脉冲的频率或时间分布的改变。
The circadian and pulsatile TSH secretion profiles were investigated in 5 females at the time of menstruation and 21 healthy males by sampling blood every 10 min for 24 h. Computer-assisted analysis, i.e. the Cluster and Desade programs, revealed means of 9.9 .+-. 1.7 (Cluster) and 11.4 .+-. 3.9 (Desade) pulses/24 h. More than 50% of the TSH pulses were detected between 2000-0400 h. Male and female subjects showed no significant difference in the basal mean and pulsatile secretion of TSH or in the TSH response to TRH (200 .mu.g). Repetition of the TSH secretion analysis in 4 healthy subjects after 1, 2, and 6 months (2 subjects) revealed a significantly better cross correlation within than between individuals (P < 0.0001). We modulated the circadian TSH secretion pattern by acute sleep withdrawal or prolonged sleep after a night of sleep withdrawal in six healthy male volunteers. Sleep withdrawal augmented the nightly TSH secretion (mean serum TSH, 2.1 .+-. 1.3 mU/L; mean TSH in sleep, 1.3 .+-. 0.5 mU/L; P < 0.05), whereas sleep after sleep withdrawal almost completely suppressed the circadian variation (mean TSH, 1.1 .+-. 0.7 mU/L; P < 0.01). This modulation is due to a significant decrease in pulse amplitude, but not to an alteration in the frequency or temporal distribution of TSH pulses.