Fiber from whole grains, but not refined grains, is inversely associated with all-cause mortality in older women: The Iowa Women's Health Study
Fiber from whole grains, but not refined grains, is inversely associated with all-cause mortality in older women: The Iowa Women's Health Study
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DOI：
10.1080/07315724.2000.10718968
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发表时间：
2000-06-01
影响因子：
3.5
通讯作者：
Kushi, LH
中科院分区：
文献类型：
--
作者：
Jacobs, DR;Pereira, MA;Kushi, LH
背景：有关谷物纤维与慢性疾病的流行病学发现的不一致，可以通过区分来自全谷物的营养丰富的纤维和来自精制雨水的营养贫乏的纤维来解释。目的：考虑到植物化学物质在谷物的外层最为多样和丰富，我们测试了与相同数量的精制谷物纤维相比，全谷物纤维的摄入与降低死亡风险相关的假设。设计：11040名绝经后妇女参加了爱荷华州妇女健康研究，从1986年至1997年12月31日，从基线到全谷物和精制谷物摄入的纤维比例不同，在此期间，124,823名观察妇女年中有1341人死亡。结果：比例风险回归多因素调整后，平均摄入1.9 g精制谷物纤维/2000 kcal和4.7 g全谷物纤维/2000 kcal的妇女死亡率比主要摄入精制谷物纤维的妇女低17% (RR = 0.83, 958 Cl=0.73- 0.93)，分别为4.5 g/2000 kcal和1.3 g全谷物纤维/2000 kcal。研究报告了谷物纤维摄入量与发病率或死亡率之间的关联，但由于没有区分纤维来源，可能会受到限制。未来的研究应该区分纤维和全纤维素。精制谷物。公共卫生政策应区分粗粮和精粮，并建议增加前者的消费。
Background: Inconsistencies in epidemiologic findings relating grain fiber to chronic disease mag be explained by differentiating nutrient-rich fiber derived from whole grain vs. nutrient-poor fiber derived from refined rain.Objective: Given that phytochemicals are most varied and abundant in the outer layers of grains, we tested the hypothesis that whole grain fiber consumption is associated with a reduced mortality risk in comparison to a similar amount of refined grain fiber.Design: 11040 postmenopausal women enrolled in the Iowa Women's Health Study, matched on total grain fiber intake, but differing in the proportion of fiber consumed from whole vs, refined grain, were followed from baseline Ln 1986 through 31 December, 1997, during which time 1341 deaths occurred in 124,823 observed woman-years.Results: After multivariate adjustment in proportional hazards regression, women who consumed on average 1.9 g refined grain fiber/2000 kcal and 4.7 g whole grain fiber/2000 kcal had a 17% lower mortality rate (RR = 0.83, 958 Cl=0.73- 0.93) than women who consumed predominantly refined gain fiber: 4.5 g/2000 kcal, hut only 1.3 g whole grain fiber/2000 kcal.Conclusion: Inferences from studies that have reported associations between grain fiber intake and morbidity or mortality may be limited by not differentiating fiber sources. Future studies should distinguish fiber from whole cs. refined grains. Public health policy should differentiate whole grains from refined, and recommend increased consumption of the former.