Altered B-cell signaling in lupus
Altered B-cell signaling in lupus
复制标题
DOI：
10.1016/j.autrev.2008.07.048
复制
发表时间：
2009-01-01
影响因子：
13.6
通讯作者：
Mohan, Chandra
中科院分区：
文献类型：
--
作者：
Liu, Kui;Mohan, Chandra
系统性红斑狼疮（SLE）是一种病因复杂的自身免疫性疾病，其主要特征是存在高滴度的自身抗体，靶向许多细胞核和细胞质抗原，并导致终末器官损伤。在各种淋巴细胞群体中已经记录了异常信号传导事件，并且它们已经构成了治疗干预的有吸引力的靶点。狼疮的小鼠模型（常规或工程）已经产生了狼疮淋巴细胞信号状态的有趣快照，并且在狼疮的小鼠模型中观察到的细胞信号中的许多改变也在患者样本中记录。在各种小鼠狼疮模型中对B细胞信号传导的分析不仅提供了信号传导状态的深入视角，并且可能提供了导致自身免疫性B细胞存活增强的潜在机制，而且还为我们提供了治疗狼疮的潜在策略。(c)2008年由Elsevier B.V.出版。
Systemic lupus erythematosus (SLE) is an autoimmune disease of complex etiology primarily characterized by the presence of high titers of autoantibodies targeting many nuclear as well as cytoplasmic antigens, with resultant end-organ damage. Aberrant signaling events have been documented in various lymphocyte populations, and they have constituted attractive targets for therapeutic intervention. Murine models of lupus (conventional or engineered) have yielded interesting snapshots of the signaling status of lupus lymphocytes, and many of these alterations in cell signaling observed in murine models of lupus have also been documented in patient samples. Analyses of B-cell signaling in various murine lupus models have not only provided an in-depth perspective of the signaling status and possibly the underlying mechanisms leading to enhanced survival of autoimmune B cells, but have also presented us with potential strategies for treating lupus. (c) 2008 Published by Elsevier B.V.