Both Sides of the Coin: Randomization from the Perspectives of Physician-Investigators and Patient-Subjects.
Both Sides of the Coin: Randomization from the Perspectives of Physician-Investigators and Patient-Subjects.
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硬币的两面：从医生-研究人员和患者-受试者的角度来看随机化。
DOI：
10.1080/10508422.2010.491764
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发表时间：
2010
影响因子：
2
通讯作者：
Kodish,Eric
中科院分区：
文献类型：
--
作者：
Yap,TsiaoYi;Kassimatis,KathleenA;Kodish,Eric
随机化是临床研究试验的“金标准”设计，被认为是减少偏倚的最佳方法。尽管在这一问题上仍存在一些争议，但我们认为，平衡是进行随机临床试验的基本伦理要求。尽管对随机化的伦理问题给予了很多关注，但这项研究设计的道德心理学尚未得到探讨。本文分析了进行这些研究所产生的伦理紧张局势，并从医生调查者和患者主体的角度探讨了这种设计的道德心理。最后，我们讨论了这种分析的实际意义。
Randomization is the “gold standard” design for clinical research trials and is accepted as the best way to reduce bias. Although some controversy remains over this matter, we believeequipoiseis the fundamental ethical requirement for conducting a randomized clinical trial. Despite much attention to the ethics of randomization, the moral psychology of this study design has not been explored. This article analyzes the ethical tensions that arise from conducting these studies and examines the moral psychology of this design from the perspectives of physician-investigators and patient-subjects. We conclude with a discussion of the practical implications of this analysis.