Yeast as a model for studying Alzheimer's disease
Yeast as a model for studying Alzheimer's disease
复制标题
DOI：
10.1111/j.1567-1364.2010.00658.x
复制
发表时间：
2010-12-01
影响因子：
3.2
通讯作者：
Macreadie, Ian
中科院分区：
文献类型：
--
作者：
Bharadwaj, Prashant;Martins, Ralph;Macreadie, Ian
阿尔茨海默病（AD）是一种以急性认知能力下降为特征的进行性神经退行性疾病。阿尔茨海默病大脑的特点是细胞外老年性淀粉样斑块、神经元内神经原纤维缠结和与记忆相关的大脑特定区域广泛的神经元细胞损失。神经元细胞功能障碍导致AD患者记忆丧失的确切机制尚不清楚。许多研究表明，酵母是一个合适的模型系统，可以解释各种由病理性蛋白质错误折叠和沉积引起的神经退行性疾病的分子机制。本文总结了利用酵母模型研究AD发病通路机制的各种研究成果。
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by acute cognitive decline. The AD brain is featured by extracellular senile amyloid plaques, intraneuronal neurofibrillary tangles and extensive neuronal cell loss in specific regions of the brain associated with memory. The exact mechanism of neuronal cell dysfunction leading to the memory loss in AD is poorly understood. A number of studies have indicated that yeast is a suitable model system to decipher the molecular mechanisms involved in a variety of neurodegenerative disorders caused by pathological protein misfolding and deposition. Here, the knowledge from various studies that have utilized a yeast model to study the mechanism of pathways involved in AD pathogenesis is summarized.