Mucins and pancreatic cancer.
Mucins and pancreatic cancer.
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DOI：
10.3390/cancers2041794
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发表时间：
2010-10-25
期刊：
影响因子：
5.2
通讯作者：
Van Seuningen I
中科院分区：
文献类型：
--
作者：
Jonckheere N;Skrypek N;Van Seuningen I
胰腺癌的特征在于与晚期诊断和缺乏有效治疗相关的通常戏剧性的结果（五年生存< 5%）。因此，临床医生迫切需要新的生物标志物和新的治疗工具来开发新的有效疗法。粘蛋白属于不断增加的O-糖蛋白家族。分泌型粘蛋白是保护上皮的粘液的主要成分，而膜结合型粘蛋白被认为在细胞-细胞和细胞-基质相互作用、细胞信号传导和调节癌细胞的生物学特性中发挥重要的生物学作用。在这篇综述中，我们将集中在胰腺癌中粘蛋白的表达模式改变，从早期肿瘤病变胰腺上皮内瘤变（PanIN）浸润性胰腺癌，和分子机制（包括遗传和表观遗传调控）和已知的控制其表达的信号通路。此外，我们还将讨论分泌型和膜结合型粘蛋白的生物学特性及其在胰腺癌发生和治疗抵抗中的关键作用。最后，我们将讨论粘蛋白作为胰腺癌潜在治疗靶点的令人兴奋的机会。
Pancreatic cancer is characterized by an often dramatic outcome (five year survival < 5%) related to a late diagnosis and a lack of efficient therapy. Therefore, clinicians desperately need new biomarkers and new therapeutic tools to develop new efficient therapies. Mucins belong to an ever increasing family of O-glycoproteins. Secreted mucins are the main component of mucus protecting the epithelia whereas membrane-bound mucins are thought to play important biological roles in cell-cell and cell-matrix interactions, in cell signaling and in modulating biological properties of cancer cells. In this review, we will focus on the altered expression pattern of mucins in pancreatic cancer, from the early neoplastic lesion Pancreatic Intraepithelial Neoplasia (PanIN) to invasive pancreatic carcinomas, and the molecular mechanisms (including genetic and epigenetic regulation) and signaling pathways known to control their expression. Moreover, we will discuss the recent advances about the biology of both secreted and membrane-bound mucins and their key roles in pancreatic carcinogenesis and resistance to therapy. Finally, we will discuss exciting opportunities that mucins offer as potential therapeutic targets in pancreatic cancer.