THE EFFECTIVENESS OF HEMODIALYSIS IN CASE OF INTOXICATION WITH PREGABALIN
THE EFFECTIVENESS OF HEMODIALYSIS IN CASE OF INTOXICATION WITH PREGABALIN
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DOI：
10.33706/jemcr.535561
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发表时间：
2019-10-01
影响因子：
0.1
通讯作者：
Ucar, Cahit
中科院分区：
文献类型：
--
作者：
Ocak, Metin;Ucar, Cahit
简介：虽然它最初是为治疗癫痫而开发的，但普瑞巴林最近也经常用于治疗神经性疼痛和焦虑症。由于其在这方面的广泛使用，报告的关于其副作用和过量的病例数量急剧上升。更具体地说，面部皮疹、头晕、嗜睡、外周水肿和体重增加、低钠血症和收缩功能障碍增加（尤其是老年人）、肝毒性和短暂性脑病的发生率在文献中报告增加。我们在此报告一例因普瑞巴林过量而诱发癫痫发作和代谢性酸中毒的病例，我们的目的是呼吁在普瑞巴林中毒的情况下，实施血液透析是治疗癫痫发作和代谢性酸中毒的快速有效方法。结论：普瑞巴林中毒表现为代谢性酸中毒和全身强直阵挛性发作，立即血液透析似乎是一种快速有效的治疗选择。
Introduction: Although it was originally developed for the treatment of epilepsy, pregabalin has also been used frequently in the management of neuropathic pain and anxiety disorders recently. Owing to its widespread use in this regard, number of the cases reported with regard to both its side-effects and overdose has been escalating dramatically. More specifically, facial rash, dizziness, drowsiness, peripheral edema and weigh gain, hyponatremia and increase in systolic dysfunction especially in the elderly, hepatotoxicity and transient encephalopathy were reported with increasing incidence in the literature.Case Report: We hereby reported a case of seizure and metabolic acidosis incited by pregabalin overdose, and our aim is to constitute an appeal for the fact that implementation of hemodialysis is a rapid and effective method in the treatment of seizure and metabolic acidosis in case of pregabalin intoxication.Conclusion: Pregabalin intoxications manifest as metabolic acidosis and generalized tonic clonic seizures, and immediate hemodialysis seems a rapid and effective treatment option.