Once daily dosing of gentamicin in infants and children
Once daily dosing of gentamicin in infants and children
复制标题
婴儿和儿童庆大霉素每日一次
DOI：
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
D. Miron
中科院分区：
文献类型：
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作者：
D. Miron
背景氨基糖苷类药物常用于儿童。婴儿和儿童的标准每日剂量（SDD）为每日两次或三次，具体取决于年龄。本文的目的是审查目前的数据有关的安全性和有效性，每日一次给药（ODD）的庆大霉素在儿童。方法.检索Medline，比较庆大霉素口服与喷雾给药在儿童中的药代动力学指标和毒性。结果共有13项描述庆大霉素在儿童中的ODD的研究被认为适合进行本综述。在大多数研究中，ODD组的稳态峰值血清庆大霉素浓度显著较高。SDD治疗组中有5 - 55%的患者记录到稳态谷浓度>2μ g/ml，而ODD组为0 - 24%。给药方式不影响分布容积;然而，ODD组的t1/2显著更长。ODD被认为是节省成本的。在一些研究中，ODD的疗效与SDD相似。结论.这些研究表明，与庆大霉素SDD相比，ODD理论上更有效，并且在新生儿中48至96小时以及在较大婴儿和儿童中3至10天的治疗中没有更高的毒性。
Background. Aminoglycosides are frequently used in children. The standard daily dosing (SDD) in infants and children is twice or three times daily depending on age. The aim of this paper is to review the current data regarding the safety and effectiveness of once daily dosing (ODD) of gentamicin in children. Methods. A Medline search was conducted for comparison studies between ODD and SDD of gentamicin in children in term of pharmacokinetic indices and toxicity. Results. Overall 13 studies describing ODD of gentamicin in children were found suitable for this review. In most studies steady state peak serum gentamicin concentrations were significantly higher in the ODD groups. Steady state trough concentrations >2 &mgr;g/ml were documented in 5 to 55% of patients treated with the SDD as compared with 0 to 24% in the ODD groups. The mode of dosing did not affect the volume of distribution; however, the t1/2 was significantly longer in the ODD groups. ODD was found to be cost-saving. In a few studies the efficacy of ODD was similar to that of SDD. Conclusions. These studies suggest that ODD compared with SDD of gentamicin is theoretically more efficacious and has no higher toxicity at 48 to 96 h in neonates and at 3 to 10 days of therapy in older infants and children.
妊娠 >/= 34 周的新生儿每日一次与两次庆大霉素给药：成本效益分析。
影响因子：
8
作者：
Thureen,PJ;Reiter,PD;Gresores,A;Stolpman,NM;Kawato,K;Hall,DM
通讯作者：
Hall,DM