Degradation rate of ultra-high molecular weight polyethylene.
Degradation rate of ultra-high molecular weight polyethylene.
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超高分子量聚乙烯的降解率。
DOI：
10.1002/jor.1100150109
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Bartel,DL
中科院分区：
文献类型：
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作者：
Kurtz,SM;Rimnac,CM;Bartel,DL
用于全关节置换的超高相对分子质量聚乙烯组件在植入前后会发生化学降解，并且这种降解与密度的增加有关。这项研究的目的是确定这些成分在空气中经伽马辐射灭菌后的平均密度变化率，作为保质期和植入时间的函数。使用密度梯度柱法，通过10个回收的Insall-Burstein/后稳定型II胫骨部件和1个手术室库存部件的加载和卸载区域的厚度获得密度分布，这些部件的初始密度分布和患者历史(如果适用)是已知的。在灭菌后的前50个月中，组件的平均密度以0.000186克/毫升/月的恒定速度增加(R2=0.54)，但负载对其影响不明显(p>；0.05)。定量降解率可能有助于验证动力学模型，以预测基于微观结构和化学过程的整体降解变化。这项研究还提出了一个假设，即超高相对分子质量聚乙烯的降解可以根据体积或平均性质的变化来模拟。
Ultra‐high molecular weight polyethylene components for total joint replacement chemically degrade before and after implantation, and the degradation is associated with an increase in density. The goal of this study was to determine the average rate of density change in these components following sterilization by gamma radiation in air as a function of shelf age and implantation time. Using the density gradient column method, density profiles were obtained through the thickness from loaded and unloded regions of 10 retrieved Insall‐Burstein/Posterior‐Stabilized II tibial components and one operating‐room inventory component for which the initial density profile and patient history (if applicable) were known. The average density of the components increased at a constant rate of 0.000186 g/cc/month during the first 50 months after sterilization (r2= 0.54) but was not significantly affected by loading (p > 0.05). The quantitative degradation rates may be useful to help verify kinetic models to predict bulk degradative changes on the basis of microstructural and chemical processes. This research also suggests the hypothesis that degradation of ultra‐high molecular weight polyethylene can be modeled in terms of changes in bulk or average properties.