Excessive centrosome abnormalities without ongoing numerical chromosome instability in a Burkitt's lymphoma.
Excessive centrosome abnormalities without ongoing numerical chromosome instability in a Burkitt's lymphoma.
复制标题
伯基特淋巴瘤中没有持续的数值染色体不稳定性，过度的中心体异常。
DOI：
10.1186/1476-4598-2-30
复制
发表时间：
2003-09-08
期刊：
影响因子：
37.3
通讯作者：
Munger, Karl
中科院分区：
文献类型：
--
作者：
Duensing, Stefan;Lee, Benjamin H;Dal Cin, Paola;Munger, Karl
Numerical and structural centrosome abnormalities are detected in various human malignancies and have been implicated in the formation of multipolar mitoses, chromosome missegregation, and chromosomal instability. Despite this association between centrosome abnormalities and cancerous growth, a causative role of centrosome aberrations in generating chromosomal instability and aneuploidy has not been universally established. We report here excessive numerical and structural centrosome abnormalities in a malignant Burkitt's lymphoma harboring the characteristic t(8;14) chromosomal translocation. Using conventional karyotyping and fluorescence in situ hybridization (FISH), we detected no signs of ongoing numerical chromosome instability, although the tumor displayed sporadic multipolar metaphases. These findings demonstrate that centrosome abnormalities are not a universal surrogate marker for chromosomal instability in malignant tumors. Moreover, our results suggest a model in which additional cellular alterations may be required to promote centrosome-related mitotic defects in tumor cells.
