Pachymic acid protects oocyte by improving the ovarian microenvironment in polycystic ovary syndrome mice
Pachymic acid protects oocyte by improving the ovarian microenvironment in polycystic ovary syndrome mice
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茯苓酸通过改善多囊卵巢综合征小鼠卵巢微环境保护卵母细胞
DOI：
10.1093/biolre/ioaa141
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发表时间：
2020-11-01
影响因子：
3.6
通讯作者：
Wang, Hai-Long
中科院分区：
文献类型：
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作者：
Fu, Xian-Pei;Xu, Lin;Wang, Hai-Long
摘要女性多囊卵巢综合征（PCOS）以内分泌紊乱伴卵母细胞质量下降为特征。本研究通过皮下注射脱氢表雄酮建立PCOS小鼠模型，以二甲双胍为阳性对照药物，研究厚青酸（PA）对PCOS小鼠内分泌及卵母细胞质量的影响。与模型组相比，PA组小鼠表现出如下变化（体重增加减慢，异常代谢改善；GV卵母细胞发育潜力增加，MII异常卵母细胞数量减少，胚胎受损；卵巢组织中卵巢相关基因表达降低，脂肪组织中促炎因子表达降低）。所有这些方面都显示出二甲双胍的相似作用。最值得注意的是，PA在改善脂肪组织炎症和线粒体异常方面优于二甲双胍。提示PA与二甲双胍具有相似的作用，可改善PCOS小鼠的内分泌环境和卵母细胞质量。上述结果提示，PA与二甲双胍具有相似的作用，可改善PCOS小鼠的内分泌环境和卵母细胞质量。图形抽象
Abstract Women with polycystic ovary syndrome (PCOS) are characterized by endocrine disorders accompanied by a decline in oocyte quality. In this study, we generated a PCOS mice model by hypodermic injection of dehydroepiandrosterone, and metformin was used as a positive control drug to study the effect of pachymic acid (PA) on endocrine and oocyte quality in PCOS mice. Compared with the model group, the mice treated with PA showed the following changes (slower weight gain, improved abnormal metabolism; increased development potential of GV oocytes, reduced number of abnormal MII oocytes, and damaged embryos; lower expression of ovarian-related genes in ovarian tissue and pro-inflammatory cytokines in adipose tissue). All these aspects show similar effects on metformin. Most notably, PA is superior to metformin in improving inflammation of adipose tissue and mitochondrial abnormalities. It is suggested that PA has the similar effect with metformin, which can improve the endocrine environment and oocyte quality of PCOS mice. These findings suggest that PA has the similar effect with metformin, which can improve the endocrine environment and oocyte quality of PCOS mice. Graphical Abstract