COMPARATIVE-STUDY OF CLINDAMYCIN, IMIPENEM, OXACILLIN AND VANCOMYCIN IN THE INFECTED GRANULOMA POUCH MODEL
COMPARATIVE-STUDY OF CLINDAMYCIN, IMIPENEM, OXACILLIN AND VANCOMYCIN IN THE INFECTED GRANULOMA POUCH MODEL
复制标题
DOI：
10.1093/jac/23.6.891
复制
发表时间：
1989-06-01
影响因子：
5.2
通讯作者：
DAVEY, P
中科院分区：
文献类型：
--
作者：
BRAUNER, E;GORBACH, S;DAVEY, P
在大鼠肉芽肿袋模型中，用克林霉素、苯唑西林或万古霉素治疗金黄色葡萄球菌感染，用克林霉素或亚胺培南治疗脆弱拟杆菌感染。该模型模拟皮下脓肿，并具有允许在同一动物中频繁采样渗出液用于细菌计数和抗生素水平的优点。在葡萄球菌感染中，所有药物均使受感染囊袋中的细菌计数降低1-1.7 log，最后一次注射后持续3 h的显著效果。克林霉素和苯唑西林的1.06-1.4 log减少持续24 h，但万古霉素在24 h时仅减少0.3 log。与苯唑西林（1.6）和万古霉素（0.8）相比，克林霉素（2.3）的感染袋中药物浓度与MIC的比值最高。与Bact fragilis感染在最后一次注射克林霉素和亚胺培南后3小时，细菌计数下降1.5 log。在24小时，克林霉素和亚胺培南的计数分别减少1.0和0.5 log。亚胺培南和克林霉素在3 h的药袋液浓度与MIC的比值分别为7.6和4.08，24 h的药袋液浓度与MIC的比值分别为1.0和2.3。
In a rat granuloma pouch model, Staphylococcus aureus infection was treated with clindamycin, oxacillin or vancomycin and Bacteroides fragilis infection with clindamycin or imipenem. The model simulates a subcutaneous abscess and has the advantage of permitting frequent sampling of exudate for bacterial counts and antibiotic levels in the same animal. In staphylococcal infection all drugs reduced the bacterial counts in the infected pouch by 1-1.7 log, with a significant effect lasting for 3 h after the last injection. A 1.06-1.4 log reduction lasted for 24 h with clindamycin and oxacillin, but there was only an 0.3 log reduction at 24 h with vancomycin. The ratio of the drug concentration in the infected pouch to the MIC was highest with clindamycin (2.3) compared to oxacillin (1.6) and vancomycin (0.8). With Bact. fragilis infection the bacterial counts dropped 1.5 log at 3 h after the last injection with clindamycin and imipenem. At 24 h the counts were reduced 1.0 log with clindamycin and 0.5 log with imipenem. The ratios of pouch fluid concentration to MIC was 7.6 and 4.08 for imipenem and clindamycin, respectively, at 3 h, and 1.0 and 2.3 for imipenem and clindamycin at 24 h.