Hippocampal neurogenesis and gene expression depend on exercise intensity in juvenile rats
Hippocampal neurogenesis and gene expression depend on exercise intensity in juvenile rats
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DOI：
10.1016/j.brainres.2008.02.080
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发表时间：
2008-05-19
期刊：
影响因子：
2.9
通讯作者：
Chen, Pei-jie
中科院分区：
文献类型：
--
作者：
Lou, Shu-jie;Liu, Jin-yan;Chen, Pei-jie
运动可以增加成年大鼠大脑中的神经发生并影响基因表达。关于运动强度如何影响幼年大鼠的神经发生和相关基因表达，人们知之甚少。在此，我们发现运动对5周龄大鼠海马区脑源性神经营养因子(BDNF)、N-甲基-D-天冬氨酸受体1(NMDAR1)、血管内皮生长因子(VEGF)和胎肝激酶-1(Flk-1)的影响具有强度依赖性。在跑步机跑步任务中，一周的低强度或中等强度运动增强了海马齿状回的神经再生。低强度运动范式(而不是高强度运动范式)导致BDNF、NMDAR1和Fik-1mRNA的表达显著增加。低强度运动组的这四种分子的基因表达水平高于高强度运动组。(C)2008爱思唯尔B.V.保留所有权利。
Exercise can increase neurogenesis and affect gene expression in the brains of adult rats. Little is known about how exercise intensity affects neurogenesis and associated gene expression in juvenile rats. Here, we show that exercise influenced neurogenesis and mRNA expression of brain derived neurotrohic factor (BDNF) N-methl-D-asparatate receptor type 1 (NMDAR1), vascular endothelial growth factor (VEGF) and fetal liver kinase-1 (Flk-1) in the hippocampus of 5 weeks old rats in an intensity-dependent manner. One week of low- or moderate-intensity exercise in a treadmill running task enhanced neurogenesis in the dentate gyrus of hippocampus. The low-, but not the high-, intensity exercise paradigm resulted in significantly increased expression of BDNF, NMDAR1, and FIk-1 mRNA. Gene expression levels in the low-intensity exercise group were greater than the high-intensity group for these four molecules. (C) 2008 Elsevier B.V. All rights reserved.