AN ANIMAL-MODEL OF ANHEDONIA - ATTENUATION OF SUCROSE CONSUMPTION AND PLACE PREFERENCE CONDITIONING BY CHRONIC UNPREDICTABLE MILD STRESS
AN ANIMAL-MODEL OF ANHEDONIA - ATTENUATION OF SUCROSE CONSUMPTION AND PLACE PREFERENCE CONDITIONING BY CHRONIC UNPREDICTABLE MILD STRESS
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DOI：
10.1007/bf02244188
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发表时间：
1991-01-01
影响因子：
3.4
通讯作者：
MUSCAT, R
中科院分区：
文献类型：
--
作者：
PAPP, M;WILLNER, P;MUSCAT, R
之前发现，长期暴露在非常温和的不可预测的压力下会抑制人们对高度可口的甜味解决方案的消费和偏好。本研究使用位置条件反射程序来研究这些效应是否源于对奖励的敏感度降低。大鼠接受慢性轻度不可预知的应激共4周。在第3周和第4周，他们接受了四次培训试验，其中奖励是在一个独特的环境中进行的，另外四次是在不同的环境中进行的非奖励试验。不同实验中使用的奖励是食物颗粒、稀释(0.7%)和浓缩(34%)蔗糖溶液，以及dl-苯丙胺硫酸盐(0.5和1.0 mg/kg)。在所有实验中，无压力的动物表现出对与奖励相关的环境的偏好增加；在有压力的动物中，这些影响被取消或大大减弱。慢性不可预测的温和压力，其强度可能与人们在日常生活中遇到的困难相当，似乎会导致对奖励的敏感度普遍下降。
Chronic exposure to very mild unpredictable stress has previously been found to depress the consumption of, and preference for, highly palatable sweet solutions. The present study used the place conditioning procedure to investigate whether these effects result from a decreased sensitivity to reward. Rats were subjected to chronic mild unpredictable stress for a total of 4 weeks. During weeks 3 and 4, they received four training trials, in which rewards were presented in a distinctive environment, and four further non-rewarded trials in a different environment. The rewards used in different experiments were food pellets, dilute (0.7%) and concentrated (34%) sucrose solutions, and dl-amphetamine sulphate (0.5 and 1.0 mg/kg). In all experiments, non-stressed animals showed an increase in preference for the environment associated with reward; in stressed animals, these effects were abolished or greatly attenuated. Chronic unpredictable mild stress, which may be comparable in intensity to the difficulties people encounter in their daily lives, appears to cause a generalized decrease in sensitivity to rewards.