Intraclass correlation coefficient and outcome prevalence are associated in clustered binary data
Intraclass correlation coefficient and outcome prevalence are associated in clustered binary data
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DOI：
10.1016/j.jclinepi.2004.08.012
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发表时间：
2005-03-01
影响因子：
7.2
通讯作者：
Campbell, MJ
中科院分区：
文献类型：
--
作者：
Gulliford, MC;Adams, G;Campbell, MJ
背景和目的：描述比例与组内相关系数(ICC)之间的关系。方法：分析从全科医学研究数据库(GPRD)获得的数据，以了解英国一般实践与卫生技术评估的结果之间的差异。结果：GPRD有188个ICC，患病率中位数为13.1%(四分位数范围IQR3.5-28.4%)和ICC中位数0.051(IQR0.011-0.094)。来自HTA审查的136ICC，中位数患病率为6.5%(IQR0.4%至20.7%)，中位数ICC为0.006(IQR0.0003至0.036)。在两个数据集中，原木ICC与原木患病率呈线性相关(GPRD，回归系数0.61，95%可信区间0.53~0.69，P<；0.001；HTA0.91，0.81~1.01，P<；0.001)。当患病率为1%时，GPRD和HTA的预测ICC分别为0.008和0.002，但当患病率为40%时，预测ICC分别为0.075(GPRD)和0.046(HTA)。结论：预后的患病率可以用来对组内相关系数的大小做出合理的假设。(C)2005 Elsevier Inc.保留所有权利。
Background and Objective: To describe the association between values for a proportion and the intraclass correlation coefficient (ICC).Methods: Analysis of data obtained from the General Practice Research Database (GPRD) for variation between United Kingdom general practices and results from a Health Technology Assessment (HTA) review for a range of outcomes in community and health services settings.Results: There were 188 ICCs from the GPRD, the median prevalence was 13.1% (interquartile range IQR 3.5 to 28.4%) and median ICC 0.051 (IQR 0.011 to 0.094). There were 136 ICCs from the HTA review, with median prevalence 6.5% (IQR 0.4 to 20.7%) and median ICC 0.006 (IQR 0.0003 to 0.036). There was a linear association of log ICC with log prevalence in both datasets (GPRD, regression coefficient 0.61, 95% confidence interval 0.53 to 0.69, P < 0.001; HTA, 0.91, 0.81 to 1.01, P < 0.001). When the prevalence was 1% the predicted ICC was 0.008 from the GPRD or 0.002 from the HTA, but when the prevalence was 40% the predicted ICC was 0.075 (GPRD) or 0.046 (HTA).Conclusion: The prevalence of an outcome may be used to make an informed assumption about the magnitude of the intraclass correlation coefficient. (C) 2005 Elsevier Inc. All rights reserved.