Metabolic syndrome in a sub-Saharan African setting: Central obesity may be the key determinant
Metabolic syndrome in a sub-Saharan African setting: Central obesity may be the key determinant
复制标题
DOI：
10.1016/j.atherosclerosis.2006.08.037
复制
发表时间：
2007-07-01
期刊：
影响因子：
5.3
通讯作者：
Mbanya, Jean-Claude
中科院分区：
文献类型：
--
作者：
Fezeu, Leopold;Balkau, Beverley;Mbanya, Jean-Claude
目的：在喀麦隆农村和城市人群中，使用三种定义确定代谢综合征（MS）的患病率，并评估MS组成部分、中心性肥胖和HOMA胰岛素抵抗（HOMA- ir）指数之间的关系。方法：对1573名成年人（农村638人，城市935人）进行个人病史调查。血压和人体测量采用标准化方法。禁食过夜后，采集OGTT前和2 h后的血样，测定血浆葡萄糖、血浆胰岛素和血脂。采用改良的WHO、NCEP-ATP III和IDF对质谱的定义。结果：中心性肥胖是该综合征最普遍的组成部分，但根据所使用的定义，患病率差异很大。高甘油三酯血症几乎不存在。WHO定义的MS患病率最高，NCEP-ATP III定义的MS患病率最低。中心性肥胖与MS组分的关系比HOMA-IR更密切。结论：不同农村/城市居民的多发性硬化症患病率差异很大，使用的定义也不同。中心性肥胖似乎是撒哈拉以南非洲地区多发性硬化症患病率的关键决定因素。许多质谱定义可能不适合非洲人口。2006爱思唯尔爱尔兰有限公司版权所有。
Objectives: To determine, in a rural and urban population in Cameroon, the prevalence of the metabolic syndrome (MS) using three definitions and to assess the association between components of the MS, central obesity and HOMA insulin resistance (HOMA-IR) index.Methods: A representative sample of 1573 adults (638 rural, 935 urban) were interviewed on their personal medical history. Blood pressure and anthropometric measures used standardised methods. After an overnight fast, blood samples were collected before and 2 h after an OGTT and plasma glucose, plasma insulin and blood lipids determined. Modified WHO, NCEP-ATP III, and IDF definitions of the MS were used.Results: Central obesity was the most prevalent component of the syndrome, but prevalence varied widely according to the definition used. Hypertriglyceridemia was almost non-existent. The highest prevalence of the MS was with the WHO definition and the lowest with the NCEP-ATP III definition. Central obesity was more tightly associated with components of the MS than was HOMA-IR.Conclusions: The prevalence of the MS varied greatly by rural/urban residence with the various definitions used. Central obesity appears to be the key determinant of the prevalence of the MS in sub Saharan Africa. Many MS definitions may not be appropriate for African populations. (c) 2006 Elsevier Ireland Ltd. All rights reserved.