Dermatoscopic and clinical features of congenital or congenital-type nail matrix nevi: A multicenter prospective cohort study by the International Dermoscopy Society.
Dermatoscopic and clinical features of congenital or congenital-type nail matrix nevi: A multicenter prospective cohort study by the International Dermoscopy Society.
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DOI：
10.1016/j.jaad.2022.01.028
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发表时间：
2022-09
影响因子：
13.8
通讯作者：
Thomas, Luc
中科院分区：
文献类型：
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作者：
Pham, Felix;Boespflug, Amelie;Duru, Gerard;Phan, Alice;Poulalhon, Nicolas;Weiler, Laura;Tanaka, Masaru;Lallas, Aimilios;Ogata, Dai;Davaine, Anne Celine;Bahadoran, Philippe;Balguerie, Xavier;Kaminska-Winciorek, Grazyna;Tromme, Isabelle;Correia, Osvaldo;Kim, Moon-Bum;Marghoob, Ashfaq A.;Martin, Linda;Guitera, Pascale;Meziane, Mariame;Miquel, Juliette;Mun, Je-Ho;Argenziano, Giuseppe;Bessis, Didier;Bourke, Johnny;Mijuskovic, Zeljko;Chiaverini, Christine;Corven-Benoit, Cloe;Droitcourt, Catherine;Skowron, Francois;Marque, Myriam;Zalaudek, Iris;Rosendahl, Cliff;Moreno-Ramirez, David;Vabres, Pierre;Haenssle, Holger;Malvehy, Josep;Puig, Susana;Robert, Caroline;Schopf, Thomas R.;Scope, Alon;Dalle, Stephane;Thomas, Luc
关键词：
先天性甲基质痣（NMN）是很难诊断，因为他们的临床特征提示成人甲下黑色素瘤。甲基质活检很难进行，特别是在儿童中。描述NMN在出生时（先天性）或出生后但在5岁之前（先天性）出现的初始临床和皮肤镜特征。从2009年到2019年，我们在30个国家的102家医院或私人医疗机构进行了前瞻性、国际性和连续的数据收集。先天性NMN 69例，先天性NMN 161例。先天性和先天型NMN主要表现为不规则的纵向微线（n = 146，64%），令人想起成人的甲下黑色素瘤。63例患者（27.8%）的远端纤维状（“刷状”）模式在先天性NMN中比先天性NMN更常见（P = 0.012）。此外，先天性NMN比先天性NMN更常显示甲周色素沉着（P = 0.029）和哈钦森征（P = 0.027）。缺乏系统的活检证实的诊断和临床和皮肤镜照片的异质性。先天性和先天型NMN表现出令人担忧的临床和皮肤镜特征，与成年期甲下黑色素瘤相似。远端纤维状（“刷状”）模式是先天性和先天性NMN的一个提示性特征。先天性甲基质痣是很难诊断的，很少有人知道他们最初的临床和皮肤镜检查的特点。先天性甲基质痣最常表现为不规则的皮肤镜下纵向细纹，类似于成人甲下黑色素瘤。远端纤维状（“刷状”）模式是良性的提示特征。
Congenital nail matrix nevi (NMN) are difficult to diagnose because they feature clinical characteristics suggestive of adult subungual melanoma. Nail matrix biopsy is difficult to perform, especially in children. To describe the initial clinical and dermatoscopic features of NMN appearing at birth (congenital) or after birth but before the age of 5 years (congenital-type). We conducted a prospective, international, and consecutive data collection in 102 hospitals or private medical offices across 30 countries from 2009 to 2019. There were 69 congenital and 161 congenital-type NMNs. Congenital and congenital-type NMN predominantly displayed an irregular pattern of longitudinal microlines (n = 146, 64%), reminiscent of subungual melanoma in adults. The distal fibrillar (“brush-like”) pattern, present in 63 patients (27.8%), was more frequently encountered in congenital NMN than in congenital-type NMN (P = .012). Moreover, congenital NMN more frequently displayed a periungual pigmentation (P = .029) and Hutchinson’s sign (P = .027) than did congenital-type NMN. Lack of systematic biopsy-proven diagnosis and heterogeneity of clinical and dermatoscopic photographs. Congenital and congenital-type NMN showed worrisome clinical and dermatoscopic features similar to those observed in adulthood subungual melanoma. The distal fibrillar (“brush-like”) pattern is a suggestive feature of congenital and congenital-type NMN. Congenital nail matrix nevi are difficult to diagnose and little is known about their initial clinical and dermatoscopic features. Congenital nail matrix nevi most often display an irregular dermatoscopic pattern of longitudinal microlines like adult subungual melanoma. The distal fibrillar (“brush-like”) pattern is a suggestive feature of benignity.
影响因子：
13.8
作者：
Kittler H;Marghoob AA;Argenziano G;Carrera C;Curiel-Lewandrowski C;Hofmann-Wellenhof R;Malvehy J;Menzies S;Puig S;Rabinovitz H;Stolz W;Saida T;Soyer HP;Siegel E;Stoecker WV;Scope A;Tanaka M;Thomas L;Tschandl P;Zalaudek I;Halpern A
通讯作者：
Halpern A
影响因子：
--
作者：
Ronger, S;Touzet, S;Thomas, L
通讯作者：
Thomas, L