Gestational glycosuria, proteinuria, and borderline hypertension in pregnancy are predictors for the later onset of maternal chronic disease
Gestational glycosuria, proteinuria, and borderline hypertension in pregnancy are predictors for the later onset of maternal chronic disease
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DOI：
10.1111/jog.15497
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发表时间：
2022-11-10
影响因子：
1.6
通讯作者：
Sago, Haruhiko
中科院分区：
文献类型：
--
作者：
Hosoya, Satoshi;Ogawa, Kohei;Sago, Haruhiko
目的：虽然妊娠期高血压疾病和妊娠期糖尿病（DM）是日后高血压、DM和肾脏疾病的危险因素，但妊娠期糖尿、蛋白尿和交界性高血压与这些慢性疾病的关系尚不清楚。方法本横断面研究于2017年4月至2020年11月在日本一家三级医院进行。分析了《妇幼保健手册》中列出的三个变量：妊娠期间的糖尿、蛋白尿和收缩压（= 140 mmHg）。采用logistic回归分析评估孕妇母亲在问卷中自述的糖尿病、肾病和高血压的发生率。结果312名产妇在分娩后平均35.8±4.2年完成问卷调查。合并糖尿的女性患糖尿病的风险显著增加（调整优势比[aOR]， 3.62； 95%可信区间[CI]， 1.21-10.9），合并蛋白尿的女性患肾脏疾病的风险显著增加（aOR, 4.07; 95% CI, 1.29-12.9）。血压为>= 140 mmHg的女性患高血压的风险显著（aOR, 4.26; 95% CI, 1.96-9.24），但血压为130-139 mmHg与高血压之间的相关性不显著（aOR, 1.72; 95% CI, 0.95-3.11）；然而，在血压升高和高血压之间观察到显著的正趋势（p < 0.001）。结论妊娠期糖尿、蛋白尿和血压升高与产妇慢性疾病的发生有关。这些标准和廉价的评估可以改善妇女的终身健康管理。
Aim Although hypertensive disorders of pregnancy and gestational diabetes mellitus (DM) are risk factors for hypertension, DM, and kidney disease in later life, the association of gestational glycosuria, proteinuria, and borderline hypertension with these chronic diseases has been unclear. Methods This cross-sectional study was conducted between April 2017 and November 2020 at a Japanese tertiary hospital. Three variables listed in the Maternal and Child Health Handbook were analyzed: glycosuria, proteinuria, and systolic blood pressure (= 140 mmHg) during pregnancy. The incidences of DM, kidney disease, and hypertension self-reported by mothers of pregnant women on a questionnaire were assessed with logistic regression analysis. Results The 312 women completed the questionnaires an average of 35.8 +/- 4.2 years after delivering their daughters. Risk for DM was significantly increased among women with glycosuria (adjusted odds ratio [aOR], 3.62; 95% confidence interval [CI], 1.21-10.9), and risk for kidney disease was significantly increased among women with proteinuria (aOR, 4.07; 95% CI, 1.29-12.9). Risk for hypertension was significant in women whose blood pressures were >= 140 mmHg (aOR, 4.26; 95% CI, 1.96-9.24), but the association between blood pressures of 130-139 mmHg and hypertension was not significant (aOR, 1.72; 95% CI, 0.95-3.11); however, a significant positive trend (p < 0.001) between increasing blood pressure and hypertension was observed. Conclusions Gestational glycosuria, proteinuria, and increased blood pressure were associated with the development of maternal chronic diseases. These standard and inexpensive assessments may improve lifelong health management in women.