Intraplantar injection of dextrorphan, ketamine or memantine attenuates formalin-induced behaviors
Intraplantar injection of dextrorphan, ketamine or memantine attenuates formalin-induced behaviors
复制标题
DOI：
10.1016/s0006-8993(97)01396-6
复制
发表时间：
1998-02-23
期刊：
影响因子：
2.9
通讯作者：
Carlton, SM
中科院分区：
文献类型：
--
作者：
Davidson, EM;Carlton, SM
局部注射目前用于人类的NMDA受体拮抗剂可能的预防作用在本研究中进行了调查。足底前处理5 mM右旋松（DEX）、10 mM美金刚（MEM）或10 mM氯胺酮（KET）均能显著减弱福尔马林诱导的举、舔行为，但对退缩行为没有影响。对照实验表明，这些药物作用可归因于局部而非全身拮抗剂的作用。我们假设这些作用是由于阻断皮肤中无髓鞘感觉轴突上的NMDA受体。这些数据表明，外周NMDA受体有助于伤害感受器的激活，并可以通过操纵来减少外周起源的疼痛。由于DEX、MEM和KET目前用于人体并且被认为是临床安全的，因此它们在治疗由外周伤害感受器活性诱导或维持的生理性或病理性疼痛状态方面具有潜在的治疗价值。局部或局部应用将避免伴随全身或鞘内注射NMDA拮抗剂的副作用。(C) 1998爱思唯尔科学有限公司
The possible prophylactic effects of local injection of NMDA receptor antagonists that are currently used in humans was investigated in the present study. Intraplantar pretreatment with either 5 mM dextrorphan (DEX), 10 mM memantine (MEM) or 10 mM ketamine (KET) significantly attenuated formalin-induced lifting and licking behaviors, however flinching behavior was not effected. Control experiments indicated that these drug actions could be attributed to local and not systemic effects of the antagonists. We hypothesize that these actions result from blocking NMDA receptors present on unmyelinated sensory axone in the skin. These data suggest that peripheral NMDA receptors contribute to nociceptor activation and can be manipulated to reduce pain of peripheral origin. Since DEX, MEM and KET are currently used in humans and considered clinically safe, they have potential therapeutic value in the treatment of physiologic or pathologic pain states which are induced or maintained by peripheral nociceptor activity. Topical or local application would avoid the side effects that can accompany systemic or intrathecal injection of NMDA antagonists. (C) 1998 Elsevier Science B.V.