Reduced central serotonin turnover in a subgroup of alcoholics?
Reduced central serotonin turnover in a subgroup of alcoholics?
复制标题
酗酒者中枢血清素周转率降低？
DOI：
10.1016/0278-5846(87)90056-x
复制
发表时间：
1987
影响因子：
5.6
通讯作者：
M. Linnoila
中科院分区：
文献类型：
--
作者：
A. Roy;M. Virkkunen;M. Linnoila
我们回顾了脑脊液(CSF)研究表明，低水平的5-羟色胺代谢产物5-HIAAA(5-HIAAA)与自杀、冲动行为和酒精中毒之间存在关联。相对较高比例的酗酒者企图并自杀，并患有冲动性反社会人格障碍。因此，我们认为可能有相当大一部分酗酒者的中枢5-羟色胺转换率降低。
We review cerebrospinal fluid (CSF) studies suggesting on association between low CSF levels of the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAAA) and suicidal and impulsive behaviour and alcoholism. Relatively high percentages of alcoholics attempt and commit suicide and have impulsive antisocial personality disorder. Therefore, we suggest that there may be a sizable subgroup of alcoholics who have a reduced central serotonin turnover.