Circuit-Based Corticostriatal Homologies Between Rat and Primate.
Circuit-Based Corticostriatal Homologies Between Rat and Primate.
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DOI：
10.1016/j.biopsych.2016.05.012
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发表时间：
2016-10-01
影响因子：
10.6
通讯作者：
Haber SN
中科院分区：
文献类型：
--
作者：
Heilbronner SR;Rodriguez-Romaguera J;Quirk GJ;Groenewegen HJ;Haber SN
理解精神疾病的神经机制需要使用啮齿动物模型；然而，啮齿动物和灵长类动物的额纹状体同源性尚不清楚。相反，纹状体中伏隔核外壳、海马投射区和杏仁核投射区（被称为纹状体情绪处理网络，EPN）在物种间是保守的。我们利用EPN与前扣带和眶额皮质（ACC/OFC）投射之间的关系来评估大鼠和猴子之间网络的相似性。我们首先比较了大鼠和猕猴EPN各主要成分的位置和范围。接下来，我们使用ACC/OFC顺行注射的解剖病例来确定皮质纹状体终端场与这些成分重叠的程度，以及彼此重叠的程度。EPN各组成部分的位置和大小在不同物种中是相似的，包括主要来自大鼠的边缘下皮层（IL）和猴子的25区（a25）的投影。其他ACC/OFC末端与IL/a25突起广泛重叠，支持内侧和外侧OFC之间的跨物种相似性。然而，不同物种的背侧ACC具有不同的连接特征。这些结果被用于根据ACC/OFC输入对猴子和大鼠纹状体进行分割。基于与EPN的连通性，并与先前的文献一致，IL和a25可能是同源物。我们也看到了内侧和外侧OFC同源性的证据。随着纹状体的分割和识别纹状体中心重叠输入，这些结果有助于将啮齿动物模型和人类病理学之间的发现转化。
Understanding the neural mechanisms of psychiatric disorders requires the use of rodent models; however, frontal-striatal homologies between rodents and primates are unclear. In contrast, within the striatum, the shell of the nucleus accumbens, the hippocampal projection zone, and the amygdala projection zone (referred to as the striatal emotion processing network, EPN) are conserved across species. We used the relationship between the EPN and projections from the anterior cingulate and orbitofrontal cortices (ACC/OFC) to assess network similarities across rats and monkeys. We first compared the location and extent of each major component of the EPN in rats and macaques. Next, we used anatomical cases with anterograde injections in ACC/OFC to determine the extent to which cortico-striatal terminal fields overlapped with these components, and with each other. The location and size of each component of the EPN were similar across species, containing projections primarily from infralimbic cortex (IL) in rats and area 25 (a25) in monkeys. Other ACC/OFC terminals overlapped extensively with IL/a25 projections, supporting cross-species similarities between medial versus lateral OFC. However, dorsal ACC had different connectivity profiles across species. These results were used to segment the monkey and rat striata according to ACC/OFC inputs. Based on connectivity with the EPN, and consistent with prior literature, IL and a25 are likely homologues. We also see evidence of homologies across medial versus lateral OFC. Along with segmenting the striatum and identifying striatal hubs of overlapping inputs, these results help to translate findings between rodent models and human pathology.