The Interferon-Signature of Sjögren's Syndrome: How Unique Biomarkers Can Identify Underlying Inflammatory and Immunopathological Mechanisms of Specific Diseases.
The Interferon-Signature of Sjögren's Syndrome: How Unique Biomarkers Can Identify Underlying Inflammatory and Immunopathological Mechanisms of Specific Diseases.
复制标题
Sjögren综合征的干扰素签名：独特的生物标志物如何识别特定疾病的潜在炎症和免疫病理学机制。
DOI：
10.3389/fimmu.2013.00142
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发表时间：
2013
影响因子：
7.3
通讯作者：
Peck AB
中科院分区：
文献类型：
--
作者：
Nguyen CQ;Peck AB
先天性免疫应答指导自身免疫性疾病中下游适应性应答的性质和特异性。先天免疫的最强标志之一是干扰素（IFN）和IFN应答/刺激基因（IRG/ISG）的上调表达。虽然在宿主应答的先天期诱导了多个IRG，但转录组数据表明不同疾病具有独特的IRG特征。干燥综合征（SjS）的特征是针对外分泌腺的慢性免疫攻击导致外分泌功能障碍，加上IFN IRG转录物的强烈上调表达。全基因组转录组分析表明，差异表达的IRGs在疾病发展过程中受到限制，因此定义了潜在的发病机制。在这里，我们回顾了先天免疫相关的干扰素签名的SjS和显示IRG/ISG集的差异基因表达如何相互作用的分子和生物学，以确定SjS发病机制的关键细节。
Innate immune responses direct the nature and specificity of downstream adaptive responses in autoimmune diseases. One of the strongest markers of innate immunity is the up-regulated expression of interferon (IFN) and IFN-responsive/stimulated genes (IRGs/ISGs). While multiple IRGs are induced during the innate phase of host responses, transcriptome data suggest unique IRG-signatures for different diseases. Sjögren’s syndrome (SjS) is characterized by chronic immune attacks against exocrine glands leading to exocrine dysfunction, plus strong up-regulated expressions of IFN IRG transcripts. Genome-wide transcriptome analyses indicate that differentially expressed IRGs are restricted during disease development and therefore define underlying etiopathological mechanisms. Here we review the innate immune-associated IFN-signature of SjS and show how differential gene expressions of IRG/ISG sets interact molecularly and biologically to identify critical details of SjS etiopathogenesis.