Autofeedback of prolactin in cultured prolactin-secreting pituitary cells.
Autofeedback of prolactin in cultured prolactin-secreting pituitary cells.
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培养的泌乳素分泌垂体细胞中催乳素的自动反馈。
DOI：
10.1159/000179140
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发表时间：
1980
期刊：
影响因子：
--
通讯作者：
J. Hershman
中科院分区：
文献类型：
--
作者：
S. Melmed;H. Carlson;J. Briggs;J. Hershman
Cultured GH3 rat pituitary tumor cells which secrete prolactin (PRL) were used to study autoregulation of rat PRL (rPRL) secretion. Acute (1 h) release of rPRL by cells in monolayer culture was inhibited by ovine PRL (oPRL; 10(-7) and 10(-8) M). Intracellular rPRL accumulation was not inhibited by exogenous oPRL. No effect of oPRL was seen during long-term (12-day) incubation of cells with oPRL (10(-7) to 10(-9) M). oPRL exerts an acute suppressive effect on rPRL release at the cellular level, but does not inhibit rPRL synthesis or long-term release.
