Human leukocyte antigen class II and cervical cancer risk: A population-based study
Human leukocyte antigen class II and cervical cancer risk: A population-based study
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DOI：
10.1086/345285
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发表时间：
2002-12-01
影响因子：
6.4
通讯作者：
Galloway, DA
中科院分区：
文献类型：
--
作者：
Madeleine, MM;Brumback, B;Galloway, DA
人类白细胞抗原（HLA）系统在向抗原特异性T细胞受体呈递肽中的关键作用可以解释为什么只有一些人乳头瘤病毒（HPV）感染的妇女进展为宫颈癌。对315例宫颈鳞癌患者和381例正常对照者进行了HLA Ⅱ类DRB 1和DQB 1基因检测。SCC风险增加与DRB 1 * 1001、DRB 1 * 1101和DQB 1 * 0301相关，风险降低与DRB 1 * 0301和DRB 1 * 13相关。在鳞状细胞肿瘤中，含有HPV-16的肿瘤与不含有HPV-16的肿瘤有3个等位基因不同：DRB 1 * 0401、DRB 1 * 07和DQB 1 * 06。SCC风险增加与DRB 1 * 0401-DQB 1 * 0301相关（比值比[OR]，1.7; 95%置信区间[CI]，1.1-2.7）和DRB 1 * 1101-DQB 1 *0301（OR，2.5; 95%CI，1.4-4.5），并且风险降低与DRB 1 * 0301-DQB 1 * 02相关（OR，0.7; 95%CI，0.5-1.0）和DRB 1 * 13-DQB 1 * 06（OR，0.6; 95%CI，0.4-0.9）单倍型。这些结果增加了某些HLA II类等位基因或等位基因组合，或与它们相关的基因，使一些妇女更容易患SCC的证据。
The critical role of the human leukocyte antigen (HLA) system in presenting peptides to antigen-specific T cell receptors may explain why only some human papillomavirus (HPV)-infected women progress to cervical cancer. HLA class II DRB1 and DQB1 genes were examined in 315 women with invasive squamous cell cervical cancer (SCC) and 381 control subjects. Increased risks of SCC were associated with DRB1* 1001, DRB1* 1101, and DQB1* 0301, and decreased risks were associated with DRB1* 0301 and DRB1* 13. Of squamous cell tumors, those containing HPV-16 were different from those not containing HPV-16 for 3 alleles: DRB1* 0401, DRB1* 07, and DQB1* 06. Increased risks of SCC were associated with DRB1* 0401-DQB1* 0301 (odds ratio [OR], 1.7; 95% confidence interval [CI], 1.1-2.7) and DRB1* 1101-DQB1*0301 (OR, 2.5; 95% CI, 1.4-4.5), and decreased risks were associated with DRB1* 0301-DQB1* 02 (OR, 0.7; 95% CI, 0.5-1.0) and DRB1* 13-DQB1* 06 (OR, 0.6; 95% CI, 0.4-0.9) haplotypes. These results add to the evidence that certain HLA class II alleles or allele combinations, or genes linked to them, make some women more susceptible to SCC.