Interscan reproducibility of computer-aided epicardial and thoracic fat measurement from noncontrast cardiac CT
Interscan reproducibility of computer-aided epicardial and thoracic fat measurement from noncontrast cardiac CT
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DOI：
10.1016/j.jcct.2011.03.009
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发表时间：
2011-05-01
影响因子：
5.4
通讯作者：
Dey, Damini
中科院分区：
文献类型：
--
作者：
Nakazato, Ryo;Shmilovich, Haim;Dey, Damini
背景：通过平扫 CT 测量的心外膜脂肪体积 (EFV) 与冠状动脉粥样硬化和主要不良心血管事件风险增加相关。平扫 CT 的 EFV 定量扫描间再现性尚未报道。 目的：我们评估了平扫 CT 的 EFV 和胸部脂肪体积 (TFV) 测量的扫描间（扫描内和扫描间）再现性。方法：我们研究了 25 名连续患者，他们使用 120 kVp、2.5 mm 的 4 排多层 CT (MDCT) 扫描两次层厚度（内扫描仪）和连续 23 名患者接受 MDCT 和电子束 CT (EBCT) 扫描，层厚度为 3 毫米（间扫描仪）。对于每次扫描，EFV 和 TFV 均由经验丰富的影像心脏病专家根据用户定义的覆盖心脏的 CT 切片范围进行测量。心外膜轮廓内 -30 至 -190 HU 内的体素被量化为 EFV。 TFV 在心脏范围内自动量化。重复性系数 (RC) 定义为重复测量对之间差异的 1.96 X SD。 结果：对于扫描仪内 (MDCT-MDCT) 和扫描仪间 (EBCT-MDCT) 数据，EFV 和 TFV 扫描间测量值的相关性很高（相关系数 >= 0.98）。对于扫描仪内同一观察者测量，RC 值最低（EFV 为 4.3%，TFV 为 5.4%）。对于扫描仪内交叉观察者测量，EFV 的 RC 值为 10.7%，TFV 的 RC 值为 9.0%。对于扫描仪间数据，RC 值范围为 6.8% 至 8.2%。结论：使用 MDCT 或 EBCT 进行心外膜和胸部脂肪测量具有高度可重复性。 (C) 2011 年心血管计算机断层扫描学会。版权所有。
BACKGROUND: Epicardial fat volume (EFV) measured from noncontrast CT is associated with coronary atherosclerosis and increased risk of major adverse cardiovascular events. Interscan reproducibility of EFV quantification from noncontrast CT has not been reported.OBJECTIVE: We evaluated the interscan (intrascanner and interscanner) reproducibility of EFV and thoracic fat volume (TFV) measurements from noncontrast CT.METHODS: We studied 25 consecutive patients who were scanned twice with 4-slice multidetector CT (MDCT), with 120 kVp, 2.5-mm slice thickness (intrascanner) and 23 consecutive patients who were scanned with MDCT and electron beam CT (EBCT) with 3-mm slice thickness (interscanner). For each scan, EFV and TFV were measured from user-defined range of CT slices covering the heart by experienced imaging cardiologists. Voxels within -30 to -190 HU within the epicardial contours was quantified as EFV. TFV was quantified within the heart range automatically. Repeatability coefficient (RC), defined as 1.96 X SD of the differences between pairs of repeated measures, was determined.RESULTS: Correlations for interscan measurements of EFV and TFV were high for both intrascanner (MDCT-MDCT) and interscanner (EBCT-MDCT) data (correlation coefficient >= 0.98). RC values were lowest (4.3% for EFV and 5.4% for TFV) for intrascanner same-observer measurement. For intrascanner cross-observer measurement, RC values were 10.7% for EFV and 9.0% for TFV. For interscanner data, RC values ranged from 6.8% to 8.2%.CONCLUSION: Epicardial and thoracic fat measurements with the use of either MDCT or EBCT are highly reproducible. (C) 2011 Society of Cardiovascular Computed Tomography. All rights reserved.