Apoptosis and signal transduction: clues to a molecular mechanism.
Apoptosis and signal transduction: clues to a molecular mechanism.
复制标题
细胞凋亡和信号转导：分子机制的线索。
DOI：
10.1016/0955-0674(93)90118-a
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发表时间：
1993
影响因子：
7.5
通讯作者：
Small,MB
中科院分区：
文献类型：
--
作者：
Lee,S;Christakos,S;Small,MB
细胞凋亡或程序性细胞死亡在脊椎动物和无脊椎动物正常胚胎和成体发育过程中特异性细胞缺失中起着重要作用。最近的证据表明，控制细胞增殖和细胞周期进程的信号转导通路也介导了对细胞外环境变化的生理反应，这些变化触发了细胞凋亡的抗增殖状态特征。
Apoptosis, or programmed cell death, plays an essential role in specific cell deletion during normal embryonic and adult development in vertebrate and invertebrate species. Recent evidence suggests that signal transduction pathways governing cellular proliferation and cell cycle progression also mediate the physiological response to changes in the extracellular environment that trigger the anti-proliferatioe state characteristic of apoptosis.