Neurodevelopmental alterations of large-scale structural networks in children with new-onset epilepsy.
Neurodevelopmental alterations of large-scale structural networks in children with new-onset epilepsy.
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DOI：
10.1002/hbm.22428
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发表时间：
2014-08
影响因子：
4.8
通讯作者：
Lin JJ
中科院分区：
文献类型：
--
作者：
Bonilha L;Tabesh A;Dabbs K;Hsu DA;Stafstrom CE;Hermann BP;Lin JJ
最近的神经影像学和行为学研究表明，新发癫痫儿童已经表现出大脑结构异常和认知障碍。大规模脑结构网络的组织在癫痫发作时是如何改变的，以及网络变化是否与认知表现有关仍不清楚。最近的研究还表明，区域脑容量协方差反映了同步的大脑发育变化。在这里，我们测试的假设，癫痫在生命早期与异常的大脑网络组织和认知。我们使用图论来研究39名新发癫痫患儿和28名健康对照儿童的基于区域体积协方差的脑结构网络。与对照组相比，新发癫痫儿童表现出次优的拓扑结构组织，增强了网络隔离，减少了全局整合。在区域层面，结构重组明显，节点从头部后部重新分布到更前部区域。癫痫大脑网络更容易受到有针对性的攻击，而不是随机攻击。最后，一个癫痫儿童亚组，即那些智商较低和执行功能较差的儿童，在网络隔离和整合之间的平衡降低。总之，研究结果表明，新发儿童癫痫的神经发育影响改变了大规模的大脑网络，导致更容易受到网络故障和认知障碍的影响。
Recent neuroimaging and behavioral studies have revealed that children with new onset epilepsy already exhibit brain structural abnormalities and cognitive impairment. How the organization of large-scale brain structural networks is altered near the time of seizure onset and whether network changes are related to cognitive performances remain unclear. Recent studies also suggest that regional brain volume covariance reflects synchronized brain developmental changes. Here, we test the hypothesis that epilepsy during early-life is associated with abnormalities in brain network organization and cognition. We used graph theory to study structural brain networks based on regional volume covariance in 39 children with new-onset seizures and 28 healthy controls. Children with new-onset epilepsy showed a suboptimal topological structural organization with enhanced network segregation and reduced global integration compared to controls. At the regional level, structural reorganization was evident with redistributed nodes from the posterior to more anterior head regions. The epileptic brain network was more vulnerable to targeted but not random attacks. Finally, a subgroup of children with epilepsy, namely those with lower IQ and poorer executive function, had a reduced balance between network segregation and integration. Taken together, the findings suggest that the neurodevelopmental impact of new onset childhood epilepsies alters large-scale brain networks, resulting in greater vulnerability to network failure and cognitive impairment.