Apatite Forming Ability and Dissolution Behavior of Boron- and Calcium-Modified Silicon Oxycarbides in Comparison to Silicate Bioactive Glass.
Apatite Forming Ability and Dissolution Behavior of Boron- and Calcium-Modified Silicon Oxycarbides in Comparison to Silicate Bioactive Glass.
复制标题
DOI：
10.1021/acsbiomaterials.9b00816
复制
发表时间：
2019-09
影响因子：
5.8
通讯作者：
Fang Xie;Isabel Gonzalo Juan;M. Arango-Ospina;R. Riedel;A. Boccaccini;E. Ionescu
中科院分区：
文献类型：
--
作者：
Fang Xie;Isabel Gonzalo Juan;M. Arango-Ospina;R. Riedel;A. Boccaccini;E. Ionescu
在体外模拟体液（SBF）中浸泡后，评估了Ca和/或B改性的碳氧化硅的生物活性。在本工作的上下文中，生物活性是指当与生理液体接触时，材料表面上羟基磷灰石结晶（生物矿化）的可能性。发现将Ca和B结合到碳氧化硅玻璃网络中增加了其生物活性，这似乎与Ca的含量成比例;因此，具有相对大的Ca/Si摩尔比（即，0.12）显示出与45 S5组合物的基准硅酸盐生物活性玻璃的生物活性特性相似的生物活性特性。采用电感耦合等离子体发射光谱（ICP-AES）研究了Ca和/或B改性的SiOC玻璃在模拟体液（SBF）试验过程中的释放动力学。已观察到Si释放动力学可与SiOC玻璃中的Ca含量相关：用Ca改性的SiOC基玻璃表现出低的Si释放活化能（即，0.07 eV），与45 S5生物活性玻璃（即，0.04 eV）;而没有Ca改性的碳氧化硅显示出更高的Si释放活化能（即，0.27 eV）。
The bioactivity of Ca and/or B modified silicon oxycarbides has been assessed in vitro upon immersion in SBF (simulated body fluid). In the context of the present work, bioactivity refers to the likeliness of hydroxyapatite crystallization (biomineralization) on the surface of a material when in contact with physiological fluids. The incorporation of Ca and B into the silicon oxycarbide glass network is found to increase its bioactivity, which seems to scale with the content of Ca; thus, SiOC glass with a relatively large Ca/Si molar ratio (i.e., 0.12) is shown to exhibit bioactive characteristics similar to those of the benchmark silicate bioactive glass of 45S5 composition. The release kinetics of the SiOC glasses modified with Ca and/or B during the SBF test was studied by inductively coupled plasma-optical emission spectroscopy. It has been observed that the Si release kinetics can be correlated with the Ca content in the SiOC glasses: SiOC based glasses modified with Ca exhibited low Si release activation energies (i.e., 0.07 eV), being comparable to that of 45S5 bioactive glass (i.e., 0.04 eV); whereas silicon oxycarbides without Ca modification showed higher activation energies for Si release (i.e., 0.27 eV).