The RNA-binding protein FCA is an abscisic acid receptor (Retracted Article. See vol 456, pg 824, 2008)
The RNA-binding protein FCA is an abscisic acid receptor (Retracted Article. See vol 456, pg 824, 2008)
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DOI：
10.1038/nature04373
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发表时间：
2006-01-19
期刊：
影响因子：
64.8
通讯作者：
Hill, RD
中科院分区：
文献类型：
--
作者：
Razem, FA;El-Kereamy, A;Hill, RD
植物激素脱落酸（阿坝）调节植物的各种生理过程。实现这一点的分子机制尚未完全了解。遗传方法的特点是阿坝信号的几个下游组件，但阿坝的受体仍然难以捉摸。虽然研究表明，几个阿坝反应基因编码RNA结合或RNA加工蛋白，没有被发现在结合阿坝的功能。在这里，我们表明，FCA，RNA结合蛋白参与开花，结合阿坝具有高亲和力的相互作用，是立体特异性和受体动力学。FCA和阿坝之间的相互作用对自主开花途径中的下游事件具有分子效应，因此对植物经历向开花过渡的能力具有分子效应。我们进一步表明，阿坝结合施加直接控制FCA介导的前体信使RNA的加工。我们的研究结果表明，FCA是一个阿坝受体参与RNA代谢和控制开花时间。
The phytohormone abscisic acid (ABA) regulates various physiological processes in plants. The molecular mechanisms by which this is achieved are not fully understood. Genetic approaches have characterized several downstream components of ABA signalling, but a receptor for ABA has remained elusive. Although studies indicate that several ABA response genes encode RNA-binding or RNA-processing proteins, none has been found to be functional in binding ABA. Here we show that FCA, an RNA-binding protein involved in flowering, binds ABA with high affinity in an interaction that is stereospecific and follows receptor kinetics. The interaction between FCA and ABA has molecular effects on downstream events in the autonomous floral pathway and, consequently, on the ability of the plant to undergo transition to flowering. We further show that ABA binding exerts a direct control on the FCA-mediated processing of precursor messenger RNA. Our results indicate that FCA is an ABA receptor involved in RNA metabolism and in controlling flowering time.