G1 EVENTS AND REGULATION OF CELL-PROLIFERATION
G1 EVENTS AND REGULATION OF CELL-PROLIFERATION
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DOI：
10.1126/science.2683075
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发表时间：
1989-11-03
期刊：
影响因子：
56.9
通讯作者：
PARDEE, AB
中科院分区：
文献类型：
--
作者：
PARDEE, AB
细胞在细胞周期的g1期为S期做准备。细胞生物学方法提供了周期动力学和g1亚阶段的知识，这是由细胞外信号决定的。通过使用生化和分子生物学技术来研究生长因子、致癌基因和抑制剂的作用，g1期间导致DNA合成的细胞内事件正在迅速被发现。许多细胞在体内处于静止状态（G0）， DNA不复制。细胞可以在G1期间被激活重新进入周期。同样，培养的细胞可以在G1和G1之间转移。这些进出g1的开关是胚胎后细胞增殖率的主要决定因素，在癌细胞中是有缺陷控制的。
Cells prepare for S phase during the G1phase of the cell cycle. Cell biological methods have provided knowledge of cycle kinetics and of substages of G1that are determined by extracellular signals. Through the use of biochemical and molecular biological techniques to study effects of growth factors, oncogenes, and inhibitors, intracellular events during G1that lead to DNA synthesis are rapidly being discovered. Many cells in vivo are in a quiescent state (G0), with unduplicated DNA. Cells can be activated to reenter the cycle during G1. Similarly, cells in culture can be shifted between G0and G1. These switches in and out of G1are the main determinants of post-embryonic cell proliferation rate and are defectively controlled in cancer cells.