Concentrations of prostaglandins D2, E2, F2 alpha, 6-keto-F1 alpha and thromboxane B2 in synovial fluid from patients with inflammatory joint disorders and osteoarthritis.
Concentrations of prostaglandins D2, E2, F2 alpha, 6-keto-F1 alpha and thromboxane B2 in synovial fluid from patients with inflammatory joint disorders and osteoarthritis.
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炎症性关节疾病和骨关节炎患者滑液中前列腺素 D2、E2、F2 α、6-酮-F1 α 和血栓素 B2 的浓度。
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发表时间：
1984
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影响因子：
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通讯作者：
D. Egg
中科院分区：
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作者：
D. Egg
用放射免疫法测定了类风湿关节炎（RA）、莱特尔病（RD）、急性痛风性关节炎（GA）和骨关节炎（OA）患者滑液中前列腺素D_2（PGD_2）、前列腺素E_2（PGE_2）、前列腺素F_2 α（PGF_2 α）、6-酮-前列腺素F_1 α（6-keto-PGF_1 α）和血栓素B_2（TXB_2）的含量。发现PGE 2是最主要的前列腺素类（pg/ml;平均值+/- S.E.M.）：RA 887 +/- 85，RD 870 +/- 71，GA 1064 +/- 155和OA 665 +/- 71。在OA患者中，发现所有前列腺素类的平均水平低于其他患者组。仅在RA患者中，可证实PGD 2/PGF 2 α、PGE 2/PGF 2 α和PGE 2/6-keto-PGF 1 α之间存在轻微相关性。关节液中的白细胞计数与前列腺素浓度之间无显著相关性，RA患者在首次采样后4周内出现复发性膝关节积液，复发样本中的PGE 2和TXB 2水平显著降低（PGE 2 792 +/- 183; TXB 2 179 +/- 33）与原始样品（PGE 2 984 +/- 146; TXB 2 239 +/- 32）相比。
The concentrations of PGD2, PGE2, PGF2 alpha, 6-keto-PGF1 alpha and TXB2 in synovial fluid from patients with rheumatoid arthritis (RA), Reiter's disease (RD), acute gouty arthritis (GA) and osteoarthritis (OA) were measured by radioimmunoassay. PGE2 was found to be the most predominant prostanoid (pg/ml; Mean +/- S.E.M.): RA 887 +/- 85, RD 870 +/- 71, GA 1064 +/- 155 and OA 665 +/- 71. In patients with OA lower mean levels of all the prostanoids were found than compared to the other groups of patients. Only in patients with RA a slight correlation between PGD2/PGF2 alpha, PGE2/PGF2 alpha and PGE2/6-keto-PGF1 alpha could be demonstrated. No significant correlations between the leucocyte cell counts in the synovial fluid and the prostanoid concentrations were found. In patients with RA developing recurrent knee joint effusions within four weeks after the first sampling significantly lower levels of PGE2 and TXB2 were found in the recurrent samples (PGE2 792 +/- 183; TXB2 179 +/- 33) than compared with the original samples (PGE2 984 +/- 146; TXB2 239 +/- 32).