Subcortical gray matter volume abnormalities in healthy bipolar offspring: Potential neuroanatomical risk marker for bipolar disorder?
Subcortical gray matter volume abnormalities in healthy bipolar offspring: Potential neuroanatomical risk marker for bipolar disorder?
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DOI：
10.1097/chi.0b013e318167656e
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发表时间：
2008-05-01
影响因子：
13.3
通讯作者：
Phillips, Mary L.
中科院分区：
文献类型：
--
作者：
Ladouceur, Cecile D.;Almeida, Jorge R. C.;Phillips, Mary L.
目的：越来越多的结构神经影像学研究表明，双相情感障碍 (BD) 与已知支持影响调节的大脑区域灰质 (GM) 体积异常有关。本研究的目的是检查健康双相情感障碍后代 (HBO) 相对于年龄匹配对照的全脑区域 GM 体积，以确定可能与 BD 风险相关的结构异常。方法：参与者包括 20 名至少一名父母被诊断患有 BD 的青少年（8-17 岁）和 22 名年龄匹配的健康个体。他们全部都没有轴心一诊断。使用 3-T 西门子扫描仪获取高分辨率磁共振成像结构图像。使用 SPM5 进行基于体素的形态测量分析。结果：根据全脑分析，相对于对照组，HBO 显着增加了左侧海马旁回/海马回的 GM 体积（p < .05 校正）。在 HBO 中，这种增加与青春期相关，但与年龄无关。在进行小体积校正后，对杏仁核和眶内侧前额叶皮层的感兴趣区域分析没有产生任何显着的组间差异。结论：HBO 中海马旁回/海马回 GM 体积增加的模式表明是 BD 风险的潜在标志。它也可以被认为是该疾病的潜在神经保护标志物，因为 HBO 不涉及当前的精神病理学。前瞻性研究检查这些区域的 GM 体积变化与 HBO 中 BD 的后续发展之间的关系，将使我们能够进一步阐明该区域在赋予 BD 风险或防止 BD 发展方面的作用。
Objective: A growing number of structural neuroimaging studies have shown that bipolar disorder (BD) is associated with gray matter (GM) volume abnormalities in brain regions known to support affect regulation. The goal of this study was to examine whole-brain regional GM volume in healthy bipolar offspring (HBO) relative to age-matched controls to identify possible structural abnormalities that may be associated with risk for BD. Method: Participants were 20 youths (8-17 years old) with at least one parent diagnosed with BD, and 22 age-matched healthy individuals. All of them were free of Axis I diagnoses. High-resolution magnetic resonance imaging structural images were acquired using a 3-T Siemens scanner. Voxel-based morphometric analyses were conducted using SPM5. Results: Relative to controls, HBO had significantly increased GM volume in left parahippocampal/hippocampal gyrus (p < .05 corrected), following whole-brain analyses. This increase was correlated with puberty but not age in HBO. Region-of-interest analyses on the amygdala and orbitomedial prefrontal cortex did not yield any significant group differences after conducting small volume correction. Conclusions: The pattern of increased GM volume in parahippocampal/hippocampal gyrus in HBO suggests a potential marker for risk for BD. It can also be considered as a potential neuroprotective marker for the disorder because HBO were free of current psychopathology. Prospective studies examining the relationship between changes in GM volume in these regions and subsequent development of BD in HBO will allow us to elucidate further the role of this region in either conferring risk for or protecting against the development of BD.