Fabrication and Arrangement of "Clickable" Nanowires by the Single-Particle Nanofabrication Technique
Fabrication and Arrangement of "Clickable" Nanowires by the Single-Particle Nanofabrication Technique
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DOI：
10.1021/jp3046406
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发表时间：
2012-08-16
影响因子：
3.7
通讯作者：
Seki, Shu
中科院分区：
文献类型：
--
作者：
Asano, Atsushi;Omichi, Masaaki;Seki, Shu
将光子或带电粒子聚焦到小的空间区域中被认为对于常规微米或纳米光刻技术中的“自上而下”小型化是必不可少的。在这里，我们描述了一种制造技术的概念“纳米线产生的粒子”，从这些限制释放，使用“点击”纳米线，以构建高度控制的生物大分子材料。本论文演示了由合成聚合物组成的纳米线的单颗粒纳米纤维技术（SPNT）的形成。由具有炔“点击”功能的聚苯乙烯衍生物，聚（苯乙烯-co-4-乙炔基苯乙烯）（PSES）组成的纳米线的制造，通过原子力显微镜证实。与未取代的聚苯乙烯相比，PSES中的炔部分实现了极高的交联效率值。通过铜催化的炔/叠氮环加成反应和亲和素-生物素相互作用，分别用高分子材料和蛋白质修饰PSES纳米线表面的炔基团。因此，PSES及其纳米线被揭示为合适的材料，用于制造纳米结构和引入各种功能材料，包括生物大分子，通过表面改性。利用SPNT技术制备的“可点击”纳米线，将有可能引发生物大分子纳米材料结构的发展。
Focusing of photons or charged particles into a small spatial area has been believed to be indispensable for "top-down" miniaturization in conventional micro- or nanolithographic techniques. Here, we describe a fabrication technique with the concept of "a nanowire produced by a particle", released from these limitations, using "Clickable" nanowires to construct highly controlled biological macromolecular materials. The present paper demonstrates the formation of nanowires composed of synthetic polymers by the single-particle nanofabrication technique (SPNT). The fabrication of nanowires composed of a polystyrene derivative with an alkyne "click" function, poly(styrene-co-4-ethynylstyrene) (PSES), was confirmed by atomic force microscopy. Alkyne moieties in PSES achieve an extremely high value of cross-linking efficiency compared with unsubstituted polystyrene. Alkyne groups on the surface of PSES nanowires were modified by polymer materials and proteins via copper-catalyzed alkyne/azide cycloaddition reactions and avidin-biotin interactions, respectively. PSES and its nanowires were thus revealed to be suitable materials for the fabrication of nanostructures and the introduction of various functional materials, including biomacromolecules, by surface modification. With "Clickable" nanowires fabricated by SPNT, it should be possible to trigger the development of the architecture of biomacromolecular nanomaterials.