Internal Structure of Nanoparticle Dimers Linked by DNA
Internal Structure of Nanoparticle Dimers Linked by DNA
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DOI：
10.1021/nn301528h
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发表时间：
2012-08-01
期刊：
影响因子：
17.1
通讯作者：
Gang, Oleg
中科院分区：
文献类型：
--
作者：
Chi, Cheng;Vargas-Lara, Fernando;Gang, Oleg
我们构建了由DNA连接的纳米颗粒二聚体。这些二聚体是可能的多尺度、分层组装中的基本单元，并作为理解DNA介导的相互作用的模型系统，特别是在纳米颗粒和DNA大小相当的非平凡区域中。我们通过散射实验和分子模拟相结合的方法详细研究了纳米粒子二聚体的结构。我们发现，对于一个给定的DNA长度，二聚体内的粒子间分离主要是由连接DNA的数量控制。我们总结了我们的研究结果在一个简单的模型，捕捉DNA桥的数量，它们的长度，粒子的曲率，并排除体积效应的相互作用。我们证明了模型的适用性，我们的结果，没有任何自由参数。因此，随着温度的升高，二聚体分离的增加可以理解为连接DNA的数量改变的结果。
We construct nanoparticle dimers linked by DNA. These dimers are basic units in a possible multiscale, hierarchical assembly and serve as a model system to understand DNA-mediated interactions, especially in the nontrivial regime when the nanoparticle and DNA are comparable in their sizes. We examine the structure of nanoparticle dimers in detail by a combination of scattering experiments and molecular simulations. We find that, for a given DNA length, the interparticle separation within the dimer is controlled primarily by the number of linking DNA. We summarize our findings in a simple model that captures the Interplay of the number of DNA bridges, their length, the particle's curvature, and the excluded volume effects. We demonstrate the applicability of the model to our results, without any free parameters. As a consequence, the increase of dimer separation with increasing temperature can be understood as a result of changing the number of connecting DNA.