REPLICATION AND DISSEMINATION OF RIFT-VALLEY FEVER VIRUS IN CULEX-PIPIENS
REPLICATION AND DISSEMINATION OF RIFT-VALLEY FEVER VIRUS IN CULEX-PIPIENS
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DOI：
10.4269/ajtmh.1984.33.176
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发表时间：
1984-01-01
影响因子：
3.3
通讯作者：
BAILEY, CL
中科院分区：
文献类型：
--
作者：
TURELL, MJ;GARGAN, TP;BAILEY, CL
Following ingestion of 104.2 to 107.2 plaque-forming units (PFU) of Rift Valley fever (RVF) virus, 662 of 850 female C. pipiens (78%) became infected. Those mosquitoes that became infected separated into 2 distinct groups: those with a nondisseminated infection limited to the gut, and those with a disseminated infection. The former group contained a median of 103.2 PFU, while those females with a disseminated infection contained a median of 105.5 PFU. Only those females with a disseminated infection were capable of transmitting virus by bite to a susceptible hamster. This is consistent with a mesenteronal escape barrier to viral dissemination. Following intrathoracic inoculation of RVF virus, all females developed a disseminated infection (26/26) and successfully transmitted virus by bite (49/49) if allowed to feed on a susceptible hamster or suckling mouse. Examination of legs and bodies separately provided a rapid and efficient method of determining dissemination status.
