Circulating levels of endothelial adhesion molecules and risk of diabetes in an ethnically diverse cohort of women
Circulating levels of endothelial adhesion molecules and risk of diabetes in an ethnically diverse cohort of women
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DOI：
10.2337/db07-0250
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发表时间：
2007-07-01
期刊：
影响因子：
7.7
通讯作者：
Liu, Simin
中科院分区：
文献类型：
--
作者：
Song, Yiqing;Manson, JoAnn E.;Liu, Simin
作为内皮功能障碍标志物的可溶性粘附分子的循环水平升高与胰岛素抵抗及其相关的代谢异常有关。然而，它们与2型糖尿病的关系仍然没有定论。我们进行了一项前瞻性巢式病例对照研究，以检查来自妇女健康倡议观察性研究的82，069名年龄在50-79岁之间的最初健康妇女的血浆E-选择素、细胞间粘附分子-1（ICAM-1）和血管细胞粘附分子-1（VCAM-1）水平与糖尿病风险之间的关系。在中位5.9年的随访期间，1,584例糖尿病病例受试者与2,198例对照受试者按年龄、种族、临床中心、抽血时间和随访时间进行匹配。在病例受试者中，生物标志物的基线中值水平均显著高于对照受试者（E-选择素，49对37 ng/ml; ICAM-1，324对280 ng/ml; VCAM-1，765对696 ng/ml [所有P值
Elevated circulating levels of soluble adhesion molecules as markers of endothelial dysfunction have been related to insulin resistance and its associated metabolic abnormalities. However, their associations with type 2 diabetes remain inconclusive. We conducted a prospective nested case-control study to examine the associations between plasma levels of E-selectin, intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) and diabetes risk among 82,069 initially healthy women aged 50-79 years from the Women's Health Initiative Observational Study. During a median follow-up of 5.9 years, 1,584 incident diabetes case subjects were matched with 2,198 control subjects by age, ethnicity, clinical center, time of blood draw, and follow-up time. Baseline median levels of the biomarkers were each significantly higher among case subjects than among control subjects (E-selectin, 49 vs. 37 ng/ml; ICAM-1, 324 vs. 280 ng/ml, VCAM-1, 765 vs. 696 ng/ml [all P values