Rheology Over Five Orders of Magnitude in Model Hydrogels: Agreement Between Strain-Controlled Rheometry, Transient Elastography, and Supersonic Shear Wave Imaging
Rheology Over Five Orders of Magnitude in Model Hydrogels: Agreement Between Strain-Controlled Rheometry, Transient Elastography, and Supersonic Shear Wave Imaging
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DOI：
10.1109/tuffc.2014.2990
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发表时间：
2014-06-01
影响因子：
3.6
通讯作者：
Tanter, Mickael
中科院分区：
文献类型：
--
作者：
Gennisson, Jean-Luc;Marcellan, Alba;Tanter, Mickael
剪切波弹性成像通过评估软组织的生物力学特性帮助医生描述病理特征。与经典流变学相比，这些技术允许在数百赫兹的频率范围内量化组织的机械特性。在本文中，超声弹性成像测量和经典的流变学进行了比较，在一个频率范围内跨越五个数量级[0.01至1200 Hz]，以表征模型凝胶在多个尺度。混合水凝胶是专门合成的，以获得材料耗散响应的微调。进行应变控制流变学（SCR）实验以获得从0.01 Hz至10 Hz的弹性模量G "和损耗模量G“，并通过拉伸试验证实。瞬态弹性成像（TE从50至400 Hz）和超声剪切成像（SSI从200至1200 Hz）用于表征聚合物在高频。在具有不同浓度的散射体的超声设置中测试两种不同的水凝胶。从低频测量，弹性模量外推在高频和SCR和TE之间和SCR和SSI之间获得了非常好的相关性（r = 0.92和r = 0.95，分别）。本文展示了剪切波弹性成像的能力，准确地成像软组织的流变特性，区分软弹性域从粘性的。它还为软材料科学提供了新的见解，因为它在高频域提供了一种流变学工具，与传统的流变学互补。
Shear wave elastography helps physicians to characterize pathologies by assessing biomechanical properties of soft tissues. Compared with classical rheology, these techniques allow the quantification of the mechanical properties of tissues in the frequency range of hundreds of hertz. In this paper, ultrasound elastographic measurements and classical rheology are compared over a frequency range spanning five orders of magnitude [0.01 to 1200 Hz] to characterize model gels at multiple scales. Hybrid hydrogels were specially synthesized to get a fine tuning of the material dissipative response. Strain-controlled rheology (SCR) experiments were performed to get the elastic moduli G '' and loss moduli G '' from 0.01 Hz to 10 Hz and were confirmed by tensile tests. Transient elastography (TE from 50 to 400 Hz) and supersonic shear imaging (SSI from 200 to 1200 Hz) were used to characterize polymers at high frequency. Two different hydrogels were tested in the ultrasound setup with different concentration of scatterers. From low-frequency measurements, elastic moduli were extrapolated at high frequency and a very good correlation was obtained between SCR and TE and between SCR and SSI (r = 0.92 and r = 0.95, respectively). This paper demonstrates the capability of shear wave elastography to accurately image rheological properties of soft tissues, to differentiate soft elastic domains from viscous ones. It also gives new insights into soft material science because it provides a rheological tool in a high-frequency domain complementary to conventional rheometry.